ArticleJournal of materials science. Materials in medicine2017
A hybrid co-culture model with endothelial cells designed for the hepatic tissue engineering.
Article in Journal of materials science. Materials in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro.Biochemical pharmacology · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
The cultured hepatic cells in vitro are prone to losing their characteristic morphologies and biological functions. To avoid this problem, a hybrid co-culture system was proposed to elucidate the effect of cellular communication on the phenotype of hepatic cells. A monolayer of endothelial cells (ECs) was co-cultured on the surface of a three-dimensional (3D) scaffold embedded with HepG2 cells. In this hybrid co-culture system, the growth of encapsulated hepatic cells is barely influenced by the co-cultured ECs. However, the liver-special functions of hepatic cells, including the albumin secretion and the expression levels of hepatocyte-specific genes, are significantly improved. It is deduced that the improved liver-special functions is likely related to the paracrine mechanisms. Hence, this hybrid co-culture model may open a window for the co-cultivation of the multi-type of cells as well as the study of cell-cell signaling interaction.
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