ArticleEuropean radiology2018
Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Quantitative coronary artery and aortic valve calcification by virtual non-contrast Images from dual-energy delayed CT scans in patients with severe aortic stenosis.The international journal of cardiovascular imaging · 2026Article
- Imaging Cardiac Amyloidosis: From Early Diagnosis to Risk Stratification and Evaluation of Treatment Efficacy.Journal of cardiovascular development and disease · 2026Review
- Clinical Significance of Extracellular Volume of Myocardium (ECV) Assessed by Computed Tomography: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Novel Insights into Non-Invasive Diagnostic Techniques for Cardiac Amyloidosis: A Critical Review.Diagnostics (Basel, Switzerland) · 2024Review
- Multimodality imaging in the diagnostic management of concomitant aortic stenosis and transthyretin-related wild-type cardiac amyloidosis.Frontiers in cardiovascular medicine · 2023Review
- Multidisciplinary Approaches for Transthyretin Amyloidosis.Cardiology and therapy · 2021Review
- Quantitative benchmarking of iodine imaging for two CT spectral imaging technologies: a phantom study.European radiology experimental · 2021Article
- Cardiac Amyloidosis: Multimodal Imaging of Disease Activity and Response to Treatment.Circulation. Cardiovascular imaging · 2021Review
- Dual Energy Differential Phase Contrast CT (DE-DPC-CT) Imaging.IEEE transactions on medical imaging · 2020Article
- The Role of Multi-modality Imaging in the Diagnosis of Cardiac Amyloidosis: A Focused Update.Frontiers in cardiovascular medicine · 2020Review
- Multi-modality imaging in transthyretin amyloid cardiomyopathy.World journal of cardiology · 2019Review
- Comprehensive morphologic and functional imaging of heart transplant patients: first experience with dynamic perfusion CT.European radiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo measure myocardium iodine concentration (MIC) in patients with cardiac amyloidosis (CA) using dual-energy computed tomography (DECT).
methodsTwenty-two patients with CA, 13 with non-amyloid hypertrophic cardiomyopathies (CH) and 10 control patients were explored with pre-contrast, arterial and 5-minute DECT acquisition (Iomeprol; 1.5 mL/kg). Inter-ventricular septum (IVS) thickness, blood pool iodine concentration (BPIC), MIC (mg/mL), iodine ratio and extra-cellular volume (ECV) were calculated.
resultsIVS thickness was significantly (p < 0.001) higher in CA (17 ± 4 mm) and CH (15 ± 3 mm) patients than in control patients (10 ± 1 mm). CA patients exhibited significantly (p < 0.001) higher 5-minute MIC [2.6 (2.3-3.1) mg/mL], 5-minute iodine ratio (0.88 ± 0.12) and ECV (0.56 ± 0.07) than CH [1.7 (1.4-2.2) mg/mL, 0.57 ± 0.07 and 0.36 ± 0.05, respectively] and control patients [1.9 (1.7-2.4) mg/mL, 0.58 ± 0.07 and 0.35 ± 0.04, respectively). CH and control patients exhibited similar values (p = 0.9). The area under the curve of 5-minute iodine ratio for the differential diagnosis of CA from CH patients was 0.99 (0.73-1.0; p = 0.001). With a threshold of 0.65, the sensitivity and specificity of 5-minute iodine ratio were 100% and 92%, respectively.
conclusionFive-minute MIC and iodine ratio were increased in CA patients and exhibited best diagnosis performance to diagnose CA in comparison to other parameters. KEY POINT: • Dual-energy computed tomography can be used to detect cardiac amyloidosis • Five-minute myocardial iodine concentration and iodine ratio increase in cardiac amyloidosis • Among iodine parameters, 5-minute iodine ratio has the best diagnosis performance.
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