Evidence map›Paper›PMID 28812028›Full record

ArticleJournal of diabetes research2017

Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus.

Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves Dos Santos, Catarina Satie Takahashi, Cristiane S Rocha, Silvana Regina Perez Orrico, Claudia V Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sâmia Cruz Tfaile CorbiDepartment of Diagnosis and Surgery, School of Dentistry, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil.
Alliny Souza BastosDepartment of Diagnosis and Surgery, School of Dentistry, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil.ORCID 0000-0002-9358-9066
Rafael NepomucenoDepartment of Diagnosis and Surgery, School of Dentistry, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil.ORCID 0000-0002-3120-0617
Thamiris CirelliDepartment of Diagnosis and Surgery, School of Dentistry, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil.
Raquel Alves Dos SantosPostgraduate Program in Sciences of the University of Franca, Franca, SP, Brazil.
Catarina Satie TakahashiDepartment of Genetics, Faculty of Medicine of Ribeirão Preto and Department of Biology, FFCLRP, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID 0000-0003-3367-539X
Cristiane S RochaDepartment of Medical Genetics, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Silvana Regina Perez OrricoDepartment of Diagnosis and Surgery, School of Dentistry, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil.
Claudia V Maurer-MorelliDepartment of Medical Genetics, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Raquel Mantuaneli Scarel-CaminagaDepartment of Morphology, School of Dentistry, Universidade Estadual Paulista (UNESP), Araraquara, SP, Brazil.ORCID 0000-0001-5068-0268
Universidade Estadual Paulista (Unesp) · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade de Franca · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite increasing research in type 2 diabetes mellitus (T2D), there are few studies showing the impact of the poor glycemic control on biological processes occurring in T2D. In order to identify potential genes related to poorly/well-controlled patients with T2D, our strategy of investigation included a primary screen by microarray (Human Genome U133) in a small group of individuals followed by an independent validation in a greater group using RT-qPCR. Ninety patients were divided as follows: poorly controlled T2D (G1), well-controlled T2D (G2), and normoglycemic individuals (G3). After using affy package in R, differentially expressed genes (DEGs) were prospected as candidate genes potentially relevant for the glycemic control in T2D patients. After validation by RT-qPCR, the obtained DEGs were as follows-G1 + G2 versus G3:

Indexed as

TranscriptomeAdultBlood GlucoseDiabetes Mellitus, Type 2FemaleGene Expression ProfilingHumansHypoglycemic AgentsMaleMicroarray AnalysisMiddle AgedBlood GlucoseHypoglycemic Agents

Identifiers

PMID28812028
PMCPMC5547755
OpenAlexW2738301894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.