ArticleCanadian journal of gastroenterology & hepatology2017
Evaluation of Adrenal Function in Nonhospitalized Patients with Cirrhosis.
Article in Canadian journal of gastroenterology & hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Creatinine-to-albumin ratio and all-cause mortality in patients with upper gastrointestinal bleeding: a retrospective study.BMC gastroenterology · 2025Article
- Adrenal insufficiency in liver diseases - pathophysiology and underlying mechanisms.Reviews in endocrine & metabolic disorders · 2024Review
- Hepatorenal Syndrome-Novel Insights into Diagnostics and Treatment.International journal of molecular sciences · 2023Review
- Adrenal Insufficiency in Cirrhosis.Journal of the Endocrine Society · 2022Review
- Evaluation of adrenal function in hemodynamically stable patients with liver cirrhosis.Clinical and experimental hepatology · 2022Article
- Acute kidney injury and hepatorenal syndrome in cirrhosis.World journal of gastroenterology · 2021Review
- Clinical and biochemical factors to predict biochemical adrenal insufficiency in hospitalized patients with indeterminate cortisol levels: a retrospective study.BMC endocrine disorders · 2020Article
- Clinical Implications, Evaluation, and Management of Hyponatremia in Cirrhosis.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with cirrhosis and advancing hepatic insufficiency may show various degrees of other organ malfunction, including brain, kidney, and lung. Several studies have also shown a high prevalence of adrenal insufficiency in cirrhotic patients that may cause hemodynamic instability. MATERIALS AND
methodsIn this study we prospectively evaluated adrenal function in a population of nonhospitalized cirrhotic patients. Categorization of liver disease severity was done according to model for end-stage liver disease (MELD) score. Adrenocorticotropic hormone stimulation testing was performed on subjects using 250
resultsOf 105 cirrhotic patients, 15.23% had evidence of adrenal insufficiency. These patients were not statistically different from those with normal adrenal function in levels of serum creatinine or bilirubin, MELD score, or presence of cirrhosis related complications. Significant differences were seen in mean international normalized ratio and serum sodium. Patients with a sodium level < 135 mEq/L had a higher rate (31.25%) of adrenal insufficiency.
conclusionAdrenal dysfunction was identified in a population of stable nonhospitalized cirrhotic patients. Our results suggest a possible role for adrenal dysfunction as a contributing factor in hyponatremia in cirrhosis independent of other known factors of neurohormonal activation secondary to systemic vasodilation.
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