Evidence map›Paper›PMID 28811980›Full record

ArticleOncoimmunology

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.

Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K Grabowska, Angelika B Riemer

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  4. The expression of ERAP1 is favorable for the prognosis and immunotherapy in colorectal cancer: a study based on the bioinformatic and immunohistochemical analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alina SteinbachImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jan WinterImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Miriam ReuschenbachDepartment of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
Renata BlatnikImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Alexandra KlevenzImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Miriam BertrandImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stephanie HoppeImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Magnus von Knebel DoeberitzDepartment of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
Agnieszka K GrabowskaImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Angelika B RiemerImmunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Research Center · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in a large array of HPV

Indexed as

Antigen processing machinery (APM)cervical cancerendoplasmic reticulum aminopeptidase 1 (ERAP1)human papillomavirus (HPV)T-cell epitopes

Identifiers

PMID28811980
PMCPMC5543819
OpenAlexW2690605297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.