Evidence map›Paper›PMID 28811900›Full record

ArticleMolecular and clinical oncology2017

SLPI and AnxA2 expression in neoplasm-free palatine tonsils is associated with smoking habit of individuals.

Elgar S Quabius, Berit Bögershausen, Lukas Getzin, Tibor Görögh, Maximilian P Gebhard, Anna S Hoffmann, Markus Hoffmann

Open access · diamondAbstract read
In one paragraph

Article in Molecular and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elgar S QuabiusDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts University, D-24105 Kiel, Germany.
Berit BögershausenDepartment of Otorhinolaryngology, University of Schleswig-Holstein, D-23538 Lübeck, Germany.
Lukas GetzinDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts University, D-24105 Kiel, Germany.
Tibor GöröghDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts University, D-24105 Kiel, Germany.
Maximilian P GebhardDepartment of Pathology, University of Schleswig-Holstein, D-23538 Lübeck, Germany.
Anna S HoffmannDepartment of Pathology, University of Schleswig-Holstein, D-23538 Lübeck, Germany.
Markus HoffmannDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts University, D-24105 Kiel, Germany.
Kiel University · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to confirm the inverse correlation between secretory leucocyte protease inhibitor (SLPI) expression, and human papillomavirus (HPV) infection previously observed in head and neck squamous-cell carcinoma, the present study retrospectively investigated the association between SLPI and Annexin A2 (AnxA2) expression, and HPV status in non-neoplastic chronic tonsillitis (n=118), and tonsillar hyperplasia (n=96) tissue. We hypothesised that smoking induces the upregulation of SLPI, resulting in reduced binding of HPV to AnxA2, a known modulator of HPV entry into the cell. SLPI and cyclin-dependent kinase inhibitor 2A (p16

Indexed as

Annexin A2HNSCChuman papillomavirussecretory leucocyte protease inhibitortonsillar cancer

Identifiers

PMID28811900
PMCPMC5547760
OpenAlexW2738053211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.