ArticlePakistan journal of medical sciences
Prognostic Factors Determining Morbidity and Mortality in Organophosphate Poisoning.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Validity of different scoring systems in prediction of intensive care unit admission and mortality in acute organophosphate poisoning.Toxicology research · 2024Article
- L-carnitine: A novel approach in management of acute cholinesterase inhibitor insecticide poisoning.Toxicology research · 2024Article
- Albuterol as an adjuvant in acute anticholinesterase pesticide poisoning: a randomized, placebo-controlled clinical trial.Toxicology research · 2024Article
- Outcome prediction using sequential organ failure assessment (SOFA) score and serum lactate levels in organophosphate poisoning.Journal of family medicine and primary care · 2023Article
- Latent class trajectories of biochemical parameters and their relationship with risk of mortality in ICU among acute organophosphorus poisoning patients.Scientific reports · 2022Article
- Comparison between various scoring systems in predicting the need for intensive care unit admission of acute pesticide-poisoned patients.Environmental science and pollution research international · 2022Article
- Hemoperfusion in combination with hemofiltration for acute severe organophosphorus pesticide poisoning: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- Clinical characteristics and early prediction of mortality risk in patients with acute organophosphate poisoning-induced shock.Frontiers in medicine · 2022Article
- A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management.Frontiers in toxicology · 2022Review
- Outcomes of elderly patients with organophosphate intoxication.Scientific reports · 2021Article
- Trajectories of vital status parameters and risk of mortality among acute organophosphorus poisoning patients - a latent class growth analysis.BMC public health · 2020Article
- Manifestations of and risk factors for acute myocardial injury after acute organophosphorus pesticide poisoning.Medicine · 2019Observational
- One-year mortality among hospital survivors of cholinesterase inhibitor poisoning based on Taiwan National Health Insurance Research Database from 2003 to 2012.BMC pharmacology & toxicology · 2018Article
- Clinical Epidemiology and Predictors of Outcome in Chlorpyrifos Poisoning in Farming and Allied Agricultural Workers in East Godavari, Andhra Pradesh.Indian journal of occupational and environmental medicineArticle
- Frequency of Acute Kidney Injury (AKI) among patients presenting with Organophosphate Poisoning at National Poison Control Centre, Karachi: A prospective cross-sectional survey.Pakistan journal of medical sciencesArticle
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7 authors.
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Abstract
objectiveOur aim in this retrospective study was to determine the factors affecting poor prognosis and mortality of organophosphate (OP) poisoning by reviewing patient data. We also reviewed present knowledge to make conclusions on certain longstanding debates in light of the literature.
methodsIn this retrospective descriptive study, patients who were admitted to and hospitalized in the emergency department (ED) or intensive care unit (ICU) of a university hospital with the diagnosis of OP poisoning between December 2010 and December 2015 were evaluated. All the data were obtained from electronic and manual patient files. A total of 80 patients were included in the study.
resultsThe mean age of the study patients was 32.4±15.0 (13-94). Forty-nine (61.2%) patients were female. Twenty-two (27.5%) patients were seriously poisoned and needed mechanical ventilation (MV) support. Low pseudocholinesterase (PChE), high creatinine (Cr), low Glasgow Coma Scale (GCS) scores and long hospitalization durations were all found to be poor prognostics in MV patients. Low PChE and high Cr levels were found to be independent predictors of the hospitalization duration and high Cr was found to be an independent predictor of the intubation duration of MV patients in regression analyses. Ten (45.5%) of the MV patients were unresponsive to medical treatment and Therapeutic plasma exchange (TPE) was performed. Seven patients were discharged healthy. Three patients with low PChE levels and comorbidities died.
conclusionsProlongation of respiratory depression necessitating MV support, comorbidities, long hospital stay, elevated creatinine, low GCS scores and low PcHE levels without regeneration in the first 48 hours of admission are all found to be poor prognostic factors for organophosphate (OP) poisoning.
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