ArticleGenetics & epigenetics2017
Consistency and Variability of DNA Methylation in Women During Puberty, Young Adulthood, and Pregnancy.
Article in Genetics & epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Distinct maternal DNA methylation associations with gestational age at early and late-mid term pregnancy in a low- and middle-income country: evaluation of biological, genetic, and psychosocial contributors.BMC pregnancy and childbirth · 2025Article
- Article
- Shared Pathophysiological Mechanisms and Genetic Factors in Early Menarche and Polycystic Ovary Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Intergenerational association of DNA methylation between parents and offspring.Scientific reports · 2024Article
- Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis.Clinical epigenetics · 2023Article
- DNA methylation dynamics during pregnancy.Frontiers in cell and developmental biology · 2023Article
- CD4Epigenetics · 2022Article
- Comparison of DNA Methylation Changes Between the Gestation Period and the After-Delivery State: A Pilot Study of 10 Women.Frontiers in nutrition · 2022Article
- Association of Maternal DNA Methylation and Offspring Birthweight.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome.Endocrine connections · 2020Article
- Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC).International journal of epidemiology · 2020Article
- Reproduction, DNA methylation and biological age.Human reproduction (Oxford, England) · 2019Article
- Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.Translational psychiatry · 2019Article
- Inter-generational resemblance of methylation levels at circadian genes and associations with phenology in the barn swallow.Scientific reports · 2019Article
- DNA Methylation Trajectories During Pregnancy.Epigenetics insights · 2019Article
- Methylome profiling of healthy and central precocious puberty girls.Clinical epigenetics · 2018Article
- DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity.Lupus science & medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Prior DNA methylation (DNA-m) analyses have identified cytosine-phosphate-guanine (CpG) sites, which show either a significant change or consistency during lifetime. However, the proportion of CpGs that are neither significantly different nor consistent over time (indifferent CpGs) is unknown. We investigated the methylation dynamics, both longitudinal changes and consistency, in women from preadolescence to late pregnancy using DNA-m of peripheral blood cells. Consistency of cell type-adjusted DNA-m between paired individuals was assessed by regressing CpGs of subsequent age on the prior, stability by intraclass correlation coefficients (>0.5), and changes by linear mixed models. In the first 2 transitions (10-18 years and 18 years to early pregnancy), 19.5% and 20.9% CpGs were consistent, but only 0.35% in the third transition (from early to late pregnancy). Significant changes in methylation were found in 0.7%, 5.6%, and 0% CpGs, respectively. Functional enrichment analyses of genes with significant changes in DNA-m in early pregnancy (5.6%) showed that the maternal DNA-m seems to reflect signaling pathways between the uterus and the trophoblast. The transition from early to late pregnancy showed low consistency/stability and no changes, suggesting the presence of a large proportion of indifferent CpGs in late pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.