Evidence map›Paper›PMID 28811670›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective.

Ziva D Cooper, Rebecca M Craft

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06544291 (Combination of THC and CBD as Novel Treatment for Co-Occurring Opioid Use Disorder and Chronic Pain), which is not on this map. Cited by 195 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 9 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06544291 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Combination of THC and CBD as Novel Treatment for Co-Occurring Opioid Use Disorder and Chronic Pain

TypeinterventionalSponsorYale UniversityRan2024 to 2028Enrolled147ConditionsChronic Pain, Opioid Use DisorderArmsCBD 300mg, CBD 600mg, Placebo 0mg
3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 9 syntheses or guidelines pooled it, 329 citations in OpenAlex.

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  8. Sex- and Gender-Based Analysis in Cannabis Treatment Outcomes: A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
  9. Highway to hell or magic smoke? The dose-dependence of ΔLearning & memory (Cold Spring Harbor, N.Y.) · 2018
    Pooled it
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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ziva D CooperDivision on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8001-2332
Rebecca M CraftDepartment of Psychology, Washington State University, Pullman, WA, USA.
Columbia University Irving Medical Center · USWashington State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent policy changes have led to significant increases in the use of cannabis for both medical and recreational purposes. Although men are more likely to endorse past month cannabis use and are more frequently diagnosed with Cannabis Use Disorder relative to women, a growing proportion of medical cannabis users are reported to be women. The increased popularity of cannabis for medical purposes and the narrowing gap in prevalence of use between men and women raises questions regarding sex-dependent effects related to therapeutic efficacy and negative health effects of cannabis and cannabinoids. The objective of this review is to provide a translational perspective on the sex-dependent effects of cannabis and cannabinoids by synthesizing findings from preclinical and clinical studies focused on sex comparisons of their therapeutic potential and abuse liability, two specific areas that are of significant public health relevance. Hormonal and pharmacological mechanisms that may underlie sex differences in the effects of cannabis and cannabinoids are highlighted.

Indexed as

CannabisSex CharacteristicsAnimalsCannabinoid Receptor ModulatorsCannabinoidsHumansMarijuana AbuseMedical MarijuanaCannabinoid Receptor ModulatorsCannabinoidsMedical Marijuana

Identifiers

PMID28811670
PMCPMC5719093
OpenAlexW2735015783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.