ArticleScientific reports2017
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Biocompatible Guanidine-Functionalized Compounds with Biofilm and Membrane Disruptive Activity Against MRSA.ACS infectious diseases · 2025Article
- Fabrication of Antibacterial and Ultraviolet Protective Wool Fabric Using Multi-Walled Carbon Nanotubes Functionalized with Guanidinylated Hyperbranched Polyethyleneimine Derivative.Materials (Basel, Switzerland) · 2025Article
- Guanethidine Enhances the Antibacterial Activity of Rifampicin Against Multidrug-Resistant Bacteria.Microorganisms · 2024Article
- A New Guanidine-Core Small-Molecule Compound as a Potential Antimicrobial Agent against Resistant Bacterial Strains.Antibiotics (Basel, Switzerland) · 2024Article
- Carbon Nanodisks Decorated with Guanidinylated Hyperbranched Polyethyleneimine Derivatives as Efficient Antibacterial Agents.Nanomaterials (Basel, Switzerland) · 2024Article
- Focused library of phenyl-fused macrocyclic amidinoureas as antifungal agents.Molecular diversity · 2022Article
- Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents.BMC chemistry · 2022Article
- Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2022Article
- Bis-Thiourea Quaternary Ammonium Salts as Potential Agents against Bacterial Strains from Food and Environmental Matrices.Antibiotics (Basel, Switzerland) · 2021Article
- Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2.Molecules (Basel, Switzerland) · 2021Article
- In Vitro and In Vivo Evaluation of the Toxic Effects of Dodecylguanidine Hydrochloride.Toxics · 2020Article
- N-Terminal guanidine derivatives of teicoplanin antibiotics strongly active against glycopeptide resistant Enterococcus faecium.The Journal of antibiotics · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last two decades, the repertoire of clinically effective antibacterials is shrinking due to the rapidly increasing of multi-drug-resistant pathogenic bacteria. New chemical classes with innovative mode of action are required to prevent a return to the pre-antibiotic era. We have recently reported the identification of a series of linear guanidine derivatives and their antibacterial properties. A batch of a promising candidate for optimization studies (compound 1) turned out to be a mixture containing two unknown species with a better biological activity than the pure compound. This serendipitous discovery led us to investigate the chemical nature of the unknown components of the mixture. Through MS analysis coupled with design and synthesis we found that the components were spontaneously generated oligomers of the original compound. Preliminary biological evaluations eventually confirmed the broad-spectrum antibacterial activity of this new family of molecules. Interestingly the symmetric dimeric derivative (2) exhibited the best profile and it was selected as lead compound for further studies.
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