Evidence map›Paper›PMID 28811651›Full record

ArticleInternational journal of obesity (2005)2018

iNKT cells prevent obesity-induced hepatic steatosis in mice in a C-C chemokine receptor 7-dependent manner.

H M Kim, B R Lee, E S Lee, M H Kwon, J H Huh, B-E Kwon, E-K Park, S-Y Chang, M-N Kweon, P-H Kim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Innate immunity and early liver inflammation.Frontiers in immunology · 2023
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

H M KimDepartment of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, Korea.ORCID 0000-0003-0046-4449
B R LeeLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
E S LeeDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
M H KwonDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
J H HuhDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
B-E KwonLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
E-K ParkLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
S-Y ChangCollege of Pharmacy, Ajou University, Suwon, Korea.
M-N KweonMucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Korea.
P-H KimDepartment of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.
H-J KoLaboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
C H ChungDepartment of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are characterized by an increase in hepatic triglyceride content with infiltration of immune cells, which can cause steatohepatitis and hepatic insulin resistance. C-C chemokine receptor 7 (CCR7) is primarily expressed in immune cells, and CCR7 deficiency leads to the development of multi-organ autoimmunity, chronic renal disease and autoimmune diabetes. Here, we investigated the effect of CCR7 on hepatic steatosis in a mouse model and its underlying mechanism. Our results demonstrated that body and liver weights were higher in the CCR7

Indexed as

AnimalsDisease Models, AnimalInflammationLiverMaleMiceMice, ObeseNatural Killer T-CellsNon-alcoholic Fatty Liver DiseaseObesityReceptors, CCR7TriglyceridesCcr7 protein, mouseReceptors, CCR7Triglycerides

Identifiers

PMID28811651
PMCPMC5803573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.