Evidence map›Paper›PMID 28811642›Full record

ArticleScientific reports2017

Octahedron Iron Oxide Nanocrystals Prohibited Clostridium difficile Spore Germination and Attenuated Local and Systemic Inflammation.

Wei-Ting Lee, Ya-Na Wu, Yi-Hsuan Chen, Shang-Rung Wu, Tsai-Miao Shih, Tsung-Ju Li, Li-Xing Yang, Chen-Sheng Yeh, Pei-Jane Tsai, Dar-Bin Shieh

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Emerging Diagnostics inInternational journal of molecular sciences · 2024
    Review
  3. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
  4. Article
  5. Novel metal peroxide nanoboxes restrainBioengineering & translational medicine · 2023
    Article
  6. Article
  7. Opportunities for Nanomedicine inAntibiotics (Basel, Switzerland) · 2021
    Review
  8. Article
  9. Article
  10. Antibacterial Activity ofFrontiers in cellular and infection microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wei-Ting LeeInstitute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Ya-Na WuInstitute of Oral Medicine, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Yi-Hsuan ChenDepartment of Medical Laboratory Science and Biotechnology, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Shang-Rung WuInstitute of Oral Medicine, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Tsai-Miao ShihInstitute of Oral Medicine, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Tsung-Ju LiInstitute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Li-Xing YangInstitute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Chen-Sheng YehDepartment of Chemistry, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan.
Pei-Jane TsaiInstitute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan. peijtsai@mail.ncku.edu.tw.
Dar-Bin ShiehInstitute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan, 701, Taiwan. dbshieh@mail.ncku.edu.tw.
National Cheng Kung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical management of Clostridium difficile infection is still far from satisfactory as bacterial spores are resistant to many chemical agents and physical treatments. Certain types of nanoparticles have been demonstrated to exhibit anti-microbial efficacy even in multi-drug resistance bacteria. However, most of these studies failed to show biocompatibility to the mammalian host cells and no study has revealed in vivo efficacy in C. difficile infection animal models. The spores treated with 500 µg/mL Fe

Indexed as

AnimalsClostridioides difficileClostridium InfectionsCryoelectron MicroscopyElectron Microscope TomographyFerric CompoundsHost-Pathogen InteractionsInflammationMiceNanoparticlesSpores, BacterialFerric Compoundsferric oxide

Identifiers

PMID28811642
PMCPMC5558001
OpenAlexW2743417055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.