ArticleScientific reports2017
Immune dysregulation in patients with carpal tunnel syndrome.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Altered blood-based biomarkers in carpal tunnel syndrome. A systematic review and meta-analysis.Musculoskeletal science & practice · 2026Pooled it
- Serum Biomarkers for Traumatic Peripheral Nerve Injury: A Systematic Review.Muscle & nerve · 2025Pooled it
- Inflammation in Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis of the Immune Profile.Journal of clinical medicine · 2026Review
- Divergent Roles of VEGF and TNF-α in Functional Impairment Among Patients with Carpal Tunnel Syndrome.International journal of molecular sciences · 2026Article
- Immune cells mediated the causal relationship between gut microbiota and carpal tunnel syndrome: A Mendelian randomization study.Medicine · 2026Article
- Ultrasound-guided hydrodissection combined with acupotomy for moderate-to-severe Carpal tunnel syndrome: electrophysiological and ultrasonographic outcomes and their potential relationship to neuroinflammatory attenuation.Frontiers in cell and developmental biology · 2026Article
- Bioinformatics Analysis of Differentially Expressed Genes in Carpal Tunnel Syndrome Using RNA Sequencing.Iranian journal of public health · 2024Article
- Higher densities of T-lymphocytes in the subsynovial connective tissue of people with carpal tunnel syndrome.PloS one · 2024Article
- Carpal Tunnel Syndrome: Neuropathic Pain Associated or Not with a Nociplastic Condition.Biomedicines · 2023Article
- Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome.Journal of personalized medicine · 2023Article
- Pain-resolving immune mechanisms in neuropathic pain.Nature reviews. Neurology · 2023Review
- Serum Levels of Inflammatory and Fibrotic Cytokines in Patients with Carpal Tunnel Syndrome and Hip Osteoarthritis.Biomedicines · 2022Article
- Regenerative Role of T Cells in Nerve Repair and Functional Recovery.Frontiers in immunology · 2022Review
- Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States.Frontiers in immunology · 2021Review
- Sex-Specific Abnormalities and Treatment-Related Plasticity of Subgenual Anterior Cingulate Cortex Functional Connectivity in Chronic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries.Journal of neuroinflammation · 2020Review
- Serum Soluble Interleukin-2 Receptor Does Not Differentiate Complex Regional Pain Syndrome from Other Pain Conditions in a Tertiary Referral Setting.Mediators of inflammation · 2020Article
- Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome.Journal of neuroinflammation · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral immunity plays a key role in maintaining homeostasis and conferring crucial neuroprotective effects on the injured nervous system, while at the same time may contribute to increased vulnerability to neuropathic pain. Little is known about the reciprocal relationship between entrapment neuropathy and peripheral immunity. This study investigated immune profile in patients with carpal tunnel syndrome (CTS), the most prevalent entrapment neuropathy. All patients exhibited neurophysiological abnormalities in the median nerve, with the majority reporting neuropathic pain symptoms. We found a significant increase in serum CCL5, CXCL8, CXCL10 and VEGF, and in CD4+ central and effector memory T cells in CTS patients, as compared to healthy controls. CCL5 and VEGF were identified as having the highest power to discriminate between patients and controls. Interestingly, and contrary to the prevailing view of CCL5 as a pro-nociceptive factor, the level of circulating CCL5 was inversely correlated with neuropathic pain intensity and median nerve motor latency. In contrast, the level of central memory T cells was positively associated with abnormal neurophysiological findings. These results suggest that entrapment neuropathy is associated with adaptive changes in the homeostasis of memory T cells and an increase in systemic inflammatory modulating cytokines/chemokines, which potentially regulate neuropathic symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.