Evidence map›Paper›PMID 28811616›Full record

ArticleScientific reports2017

Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and

Jing Yang, Jian Yang, Lu Wang, Anna Moore, Steven H Liang, Chongzhao Ran

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Comparing endoscopic ultrasonography and double contrast-enhanced ultrasonography in the preoperative diagnosis of gastric stromal tumor.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  2. Review
  3. Article
  4. Article
  5. Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021
    Review
  6. Comparative [Adipocyte · 2020
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Jing YangMolecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 01890, USA.
Jian YangMolecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 01890, USA.
Lu WangDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, 02114, USA.
Anna MooreMolecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 01890, USA.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, 02114, USA.ORCID 0000-0003-1413-6315
Chongzhao RanMolecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 01890, USA. cran@nmr.mgh.harvard.edu.ORCID 0000-0002-3892-4108
Harvard University · US

Funding

New PET tracers for neuroimaging of FAAH in endocannabinoid signalingK01DA038000 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2014 to 2018
$927k
Imaging brown adipose tissue and monitoring browningR56DK108813 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAN, CHONGZHAO · 2016 to 2017
$567k
NIDA NIH HHS K01 DA038000NIDDK NIH HHS R56 DK108813
6 · The paper itself

Abstract

PET imaging is a widely applicable but a very expensive technology. On-site synthesis is one important contributor to the high cost. In this report, we demonstrated the feasibility of a synthesis-free method for PET imaging of brown adipose tissue (BAT) and translocator protein 18 kDa (TSPO) via a combination of disulfiram, an FDA approved drug for alcoholism, and

Indexed as

Copper RadioisotopesDisulfiramPositron-Emission TomographyAdipose Tissue, BrownAnimalsBiomarkersLigandsMiceMolecular ImagingProtein BindingReceptors, GABABiomarkersBzrp protein, mouseCopper-64Copper RadioisotopesDisulfiramLigandsReceptors, GABA

Identifiers

PMID28811616
PMCPMC5557754
OpenAlexW2949443295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.