ArticleScientific reports2017
Identification of ciguatoxins in a shark involved in a fatal food poisoning in the Indian Ocean.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Automatic MS/MS Data Mining Strategy for Rapid Screening of Polyether Toxins Derived fromAnalytical chemistry · 2025Article
- Application of High-Resolution Mass Spectrometry for Ciguatoxin Detection in Fish from the Asia-Pacific Region.Toxins · 2025Article
- First Confirmed Occurrence of Ciguatera Poisoning in the UK from Imported Pinjalo Snapper (Marine drugs · 2025Article
- Marine Algal Toxins and Public Health: Insights from Shellfish and Fish, the Main Biological Vectors.Marine drugs · 2024Review
- Article
- Concentration ciguatoxins in fillet of fish: A global systematic review and meta-analysis.Heliyon · 2023Review
- Review
- Article
- Review
- Reductive Amination for LC-MS Signal Enhancement and Confirmation of the Presence of Caribbean Ciguatoxin-1 in Fish.Toxins · 2022Article
- Evaluating Age and Growth Relationship to Ciguatoxicity in Five Coral Reef Fish Species from French Polynesia.Marine drugs · 2022Article
- Identification of New CTX Analogues in Fish from the Madeira and Selvagens Archipelagos by Neuro-2a CBA and LC-HRMS.Marine drugs · 2022Article
- Current Trends and New Challenges in Marine Phycotoxins.Marine drugs · 2022Review
- Ciguatoxin Detection in Flesh and Liver of Relevant Fish Species from the Canary Islands.Toxins · 2022Article
- Selective extraction of gambierone and related metabolites in Gambierdiscus silvae using m-aminophenylboronic acid-agarose gel and liquid chromatography-high-resolution mass spectrometric detection.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2022Article
- Extraction and LC-MS/MS Analysis of Ciguatoxins: A Semi-Targeted Approach Designed for Fish of Unknown Origin.Toxins · 2021Article
- Ciguatera in the Indian Ocean with Special Insights on the Arabian Sea and Adjacent Gulf and Seas: A Review.Toxins · 2021Review
- Critical Review and Conceptual and Quantitative Models for the Transfer and Depuration of Ciguatoxins in Fishes.Toxins · 2021Review
- Ciguatera Mini Review: 21st Century Environmental Challenges and the Interdisciplinary Research Efforts Rising to Meet Them.International journal of environmental research and public health · 2021Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe food poisoning events after the consumption of sharks have been reported since the 1940s; however, there has been no clear understanding of their cause. Herein, we report for the first time the presence of ciguatoxins (CTXs) in sharks. The identification by mass spectrometry of CTXs, including two new analogues, in a bull shark (Carcharhinus leucas) that was consumed by humans, causing the poisoning and death of 11 people in Madagascar in 2013 is described. Typical neurotoxic ciguatera symptoms were recorded in patients, and toxicological assays on extracts of the shark demonstrated CTX-like activity. These results confirm this episode as a ciguatera poisoning event and expand the range of pelagic fish species that are involved in ciguatera in the Indian Ocean. Additionally, gambieric acid D, a molecule originally described in CTX-producing microalgae, was identified for the first time in fish. This finding can contribute to a better understanding of trophic relations within food webs. The present work confirms that consumption of sharks from the Indian Ocean should be considered a ciguatera risk, and actions should be taken to evaluate its magnitude and risk in order to manage shark fisheries.
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