ArticleScientific reports2017
High-performance therapeutic quercetin-doped adhesive for adhesive-dentin interfaces.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Pooled it
- Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Coadministration of fluoride, trimetaphosphate, and quercetin reduces dentin erosive wear in vitro.Clinical oral investigations · 2026Article
- Quercetin as a Natural Adjunct in Managing Plaque and Gingivitis in Adults: A Randomized Controlled Trial.Cureus · 2026Article
- Biological Activity of Polyquercetin Nanoparticles: A Potential Antimicrobial Agent.Current microbiology · 2026Article
- The contribution of different types of polyphenols to bonding performance by enhancing the stabilization of the hybrid layer.Clinical oral investigations · 2026Article
- Application of a chlorinated catechol monomer to enhance dentin bond durability and impart antibacterial activity.BMC oral health · 2026Article
- Improvement of dentin bonding via adhesive monomers with multiple hydrogen bonding moieties.Acta biomaterialia · 2025Article
- Exploring the impact of quercetin on the growth and biofilm formation of Leptospira interrogans.Folia microbiologica · 2025Article
- Biomineralization of dental tissues with natural drugs: a comprehensive review.The Saudi dental journal · 2025Review
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Natural Antibacterial Compounds with Potential for Incorporation into Dental Adhesives: A Systematic Review.Polymers · 2024Review
- Optimization of Functional Toothpaste Formulation Containing Nano-Hydroxyapatite and Birch Extract for Daily Oral Care.Materials (Basel, Switzerland) · 2023Article
- Article
- Effects of Tea Polyphenols and Theaflavins on Three Oral Cariogenic Bacteria.Molecules (Basel, Switzerland) · 2023Article
- Crosslinking Improve Demineralized Dentin Performance and Synergistically Promote Biomimetic Mineralization by CaP_PILP.ACS omega · 2023Article
- Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface.Frontiers in dental medicine · 2023Review
- Functional liposome loaded curcumin for the treatment ofFrontiers in chemistry · 2023Article
- Role of Natural Cross Linkers in Resin-Dentin Bond Durability: A Systematic Review and Meta-Analysis.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost half of dental restorations have failed in less than 10 years, and approximately 60% of practice time has been consumed to replace these dental restorations. As such, contemporary dentin adhesives should be modified to treat secondary caries and prevent the degradation of adhesive-dentin interfaces. To achieve this goal, we developed a versatile therapeutic adhesive in the present study by incorporating quercetin, which is a naturally derived plant extract, into a commercial adhesive at three concentrations (100, 500 and 1000 µg/mL). An unmodified adhesive served as a control. The antibacterial ability on Streptococcus mutans biofilm, conversion degree, microtensile bond strength, failure modes, in situ zymography, nanoleakage expression and cytotoxicity of quercetin-doped adhesive were comprehensively evaluated. Results showed that the quercetin-doped adhesive (500 µg/mL) preserved its bonding properties against collagenase ageing and inhibited the growth of S. mutans biofilm. Efficient bonding interface sealing ability, matrix metalloproteinase inhibition and acceptable biocompatibility were also achieved. Thus, a simple, safe and workable strategy was successfully developed to produce therapeutic adhesives for the extension of the service life of adhesive restorations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.