Evidence map›Paper›PMID 28811580›Full record

ArticleScientific reports2017

Βeta 2-glycoprotein I protects mice against gram-negative septicaemia in a sexually dimorphic manner.

Fatima El-Assaad, Miao Qi, Alice Kizny Gordon, Jian Qi, Shangwen Dong, Freda Passam, James Crofton Weaver, Bill Giannakopoulos, Steven Anthony Krilis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. The Secretome Deregulations in a Rat Model of Endotoxemic Shock.Oxidative medicine and cellular longevity · 2021
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fatima El-AssaadSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.
Miao QiSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.
Alice Kizny GordonDepartment of Infectious Disease, Immunology and Sexual Health, St George Hospital, Kogarah, New South Wales, Australia.
Jian QiSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.
Shangwen DongSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.
Freda PassamSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.
James Crofton WeaverSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.
Bill GiannakopoulosSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia. bill.giannakopoulos@unsw.edu.au.
Steven Anthony KrilisSt George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales Australia, Research and Education Centre, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) reduces LPS-induced inflammation in male mice. In the present study using a more robust infection model of septicaemia the role of β2GPI is examined in both male and female wild type (WT) and β2GPI deficient (β2GPI

Indexed as

Animalsbeta 2-Glycoprotein ICytokinesDisease Models, AnimalEndotoxemiaEscherichia coliEscherichia coli InfectionsFemaleGenetic Predisposition to DiseaseHumansLipopolysaccharidesMaleMiceMice, KnockoutOrgan SpecificitySepsisbeta 2-Glycoprotein ICytokinesLipopolysaccharides

Identifiers

PMID28811580
PMCPMC5557990

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.