ArticleScientific reports2017
Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Age-related DNA methylation on Y chromosome and their associations with total mortality among Chinese males.Aging cell · 2022Pooled it
- The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.BMC medicine · 2023Trial
- A robust computational framework for methylation age and disease-risk prediction based on pairwise learning.Nature computational science · 2026Article
- Stratifying high-risk prediabetes clusters using blood-based epigenetic markers.Biomarker research · 2026Article
- Sex-Chromosome-Dependent Ageing in Female Heterogametic Methylomes.Molecular ecology · 2025Article
- Article
- Epigenetic profiles integrated with transcriptomic reveal the difference between COPD and PRISm in KOCOSS-NIH.Functional & integrative genomics · 2025Article
- Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins.Epigenomes · 2024Article
- Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome.Epigenetics · 2023Article
- Aging and obesity prime the methylome and transcriptome of adipose stem cells for disease and dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Article
- Age patterns of intra-pair DNA methylation discordance in twins: Sex difference in epigenomic instability and implication on survival.Aging cell · 2021Article
- Ageing-associated changes in DNA methylation in X and Y chromosomes.Epigenetics & chromatin · 2021Article
- Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence.Human molecular genetics · 2021Article
- Epigenome-wide association study of maternal hemoglobin A1c in pregnancy and cord blood DNA methylation.Epigenomics · 2021Article
- Novel DNA methylation marker discovery by assumption-free genome-wide association analysis of cognitive function in twins.Aging cell · 2021Article
- Heterochromatin: an epigenetic point of view in aging.Experimental & molecular medicine · 2020Review
- Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples.Genome medicine · 2020Article
- Article
- The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging.Frontiers in aging neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methylated CpGs and replicated them in two independent Danish cohorts. The double-replicated CpGs were characterized by distribution over gene regions and location in relation to CpG islands. The replicated CpGs were further characterized by involvement in biological pathways to study their functional implications in aging. We identified 67,604 age-associated CpG sites reaching genome-wide significance of FWER <0.05, 86% demethylated with increasing age. Double-replication resulted in 5,168 CpGs (39% age-methylated and 61% age-demethylated) which were characterized by high concentration of age-methylated CpGs at 1stExon and TSS200 and a dominant pattern of age-demethylated CpGs at other gene regions, and by overwhelming age-related methylation in CpG islands and demethylation at shore/shelf and open sea. The differential distribution patterns over gene regions for methylated and demethylated CpGs both relate to reduced gene activity during aging. Pathway analysis showed that age-dependent methylations were especially involved in cellular signalling activities while demethylations particularly linked to functions of the extracellular matrix, all implicated in the aging process and age-related disease risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.