Evidence map›Paper›PMID 28811467›Full record

ArticleNature communications2017

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.

Woelsung Yi, Sanjay Gupta, Edd Ricker, Michela Manni, Rolf Jessberger, Yurii Chinenov, Henrik Molina, Alessandra B Pernis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 63 citations in OpenAlex.

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  12. Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  13. Article
  14. T cell help in the autoreactive germinal center.Scandinavian journal of immunology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Woelsung YiAutoimmunity and Inflammation Program, Hospital for Special Surgery, 535 East 70th Street, New York, New York, 10021, USA.
Sanjay GuptaAutoimmunity and Inflammation Program, Hospital for Special Surgery, 535 East 70th Street, New York, New York, 10021, USA.
Edd RickerGraduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, Box 65, New York, New York, 10021, USA.
Michela ManniAutoimmunity and Inflammation Program, Hospital for Special Surgery, 535 East 70th Street, New York, New York, 10021, USA.
Rolf JessbergerInstitute of Physiological Chemistry, Technische Universität Dresden, Fiedlerstrasse 42, MTZ, 01307, Dresden, Germany.
Yurii ChinenovArthritis and Tissue Degeneration Program, Hospital for Special Surgery, 535 East 70th Street, New York, New York, 10021, USA.
Henrik MolinaProteomics Resource Center, The Rockefeller University, 1230 York Avenue, Box 105, New York, New York, 10065, USA.
Alessandra B PernisAutoimmunity and Inflammation Program, Hospital for Special Surgery, 535 East 70th Street, New York, New York, 10021, USA. pernisa@hss.edu.
Hospital for Special Surgery · USCornell University · USRockefeller University · USTU Dresden · DE

Funding

Rho GTPase-mediated pathways in autoimmune arthritisR01AI083440 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI PERNIS, ALESSANDRA B · 2012 to 2016
$2.2M
Novel signaling pathways in lupus pathogenesisR01AR064883 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI PERNIS, ALESSANDRA B · 2015 to 2019
$1.9M
Regulatory Mechanisms Controlling TFH Responses in LupusR01AR070146 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI PERNIS, ALESSANDRA B · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI083440NIAMS NIH HHS R01 AR064883NIAMS NIH HHS R01 AR070146
6 · The paper itself

Abstract

Post-transcriptional modifications can control protein abundance, but the extent to which these alterations contribute to the expression of T helper (T

Indexed as

AutoimmunityAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCell Cycle ProteinsDNA-Binding ProteinsEukaryotic Initiation Factor-4EEukaryotic Initiation FactorsGuanine Nucleotide Exchange FactorsHumansLupus Erythematosus, SystemicMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsAdaptor Proteins, Signal TransducingCarrier ProteinsCell Cycle ProteinsDEF6 protein, humanDNA-Binding ProteinsEif4ebp1 protein, mouseEukaryotic Initiation Factor-4EEukaryotic Initiation FactorsGuanine Nucleotide Exchange FactorsMechanistic Target of Rapamycin Complex 1Nuclear ProteinsPhosphoproteinsProto-Oncogene Proteins c-bcl-6

Identifiers

PMID28811467
PMCPMC5557982
OpenAlexW2743325145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.