Evidence map›Paper›PMID 28811387›Full record

ArticleGenetics2017

Selection Constrains High Rates of Tandem Repetitive DNA Mutation in

Jullien M Flynn, Ian Caldas, Melania E Cristescu, Andrew G Clark

Abstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  19. Article
  20. Satellite DNA evolution: old ideas, new approaches.Current opinion in genetics & development · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jullien M FlynnDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850 jmf422@cornell.edu.ORCID 0000-0001-5999-4781
Ian CaldasDepartment of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14850.
Melania E CristescuDepartment of Biology, McGill University, Montreal, Quebec, Canada.
Andrew G ClarkDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850.

Funding

Heterochromatin and satellite repeat sequence variation in natural populationsR01GM119125 · NIGMS · CORNELL UNIVERSITY · PI BARBASH, DANIEL A, CLARK, ANDREW G · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM119125
6 · The paper itself

Abstract

A long-standing evolutionary puzzle is that all eukaryotic genomes contain large amounts of tandemly-repeated DNA whose sequence motifs and abundance vary greatly among even closely related species. To elucidate the evolutionary forces governing tandem repeat dynamics, quantification of the rates and patterns of mutations in repeat copy number and tests of its selective neutrality are necessary. Here, we used whole-genome sequences of 28 mutation accumulation (MA) lines of

Indexed as

Mutation RateSelection, GeneticTandem Repeat SequencesAnimalsDaphniaDNA, SatelliteMutation AccumulationDNA, Satellitemutation accumulation (MA)satellite evolutionstabilizing selectiontandem repeats

Identifiers

PMID28811387
PMCPMC5629333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.