ArticleProceedings of the National Academy of Sciences of the United States of America2017
Angular reconstitution-based 3D reconstructions of nanomolecular structures from superresolution light-microscopy images.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 48 citations in OpenAlex.
- SuperResNET: Model-Free Single-Molecule Network Analysis Software Achieves Molecular Resolution of Nup96.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025Article
- Insights into protein structure using cryogenic light microscopy.Biochemical Society transactions · 2023Review
- Maximum-likelihood model fitting for quantitative analysis of SMLM data.Nature methods · 2023Article
- Mapping molecular complexes with super-resolution microscopy and single-particle analysis.Open biology · 2022Review
- Article
- Super-resolution imaging: when biophysics meets nanophotonics.Nanophotonics (Berlin, Germany) · 2022Review
- 3D particle averaging and detection of macromolecular symmetry in localization microscopy.Nature communications · 2021Article
- The emergence of phase separation as an organizing principle in bacteria.Biophysical journal · 2021Review
- Article
- Single-molecule localization microscopy.Nature reviews. Methods primers · 2021Article
- 3D Structure From 2D Microscopy Images Using Deep Learning.Frontiers in bioinformatics · 2021Review
- CENP-A nucleosome clusters form rosette-like structures around HJURP during G1.Nature communications · 2019Article
- SMoLR: visualization and analysis of single-molecule localization microscopy data in R.BMC bioinformatics · 2019Article
- Article
- Template-free 2D particle fusion in localization microscopy.Nature methods · 2018Article
- Multicolor single-particle reconstruction of protein complexes.Nature methods · 2018Article
- Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles.Journal of visualized experiments : JoVE · 2018Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
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Abstract
Superresolution light microscopy allows the imaging of labeled supramolecular assemblies at a resolution surpassing the classical diffraction limit. A serious limitation of the superresolution approach is sample heterogeneity and the stochastic character of the labeling procedure. To increase the reproducibility and the resolution of the superresolution results, we apply multivariate statistical analysis methods and 3D reconstruction approaches originally developed for cryogenic electron microscopy of single particles. These methods allow for the reference-free 3D reconstruction of nanomolecular structures from two-dimensional superresolution projection images. Since these 2D projection images all show the structure in high-resolution directions of the optical microscope, the resulting 3D reconstructions have the best possible isotropic resolution in all directions.
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