ArticleEBioMedicine2017
Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo.
Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- In Vitro Antiproliferative Effects of Benzothiazole-Based Aminosquaraine Dyes Against Cancer Cell Lines.Molecules (Basel, Switzerland) · 2026Article
- Development of 3D skin equivalents for application in photodynamic biostimulation therapy assays using curcumin nanocapsules.Heliyon · 2024Article
- Self-Assembled BODIPY Derivative with A-D-A Structure as Organic Nanoparticles for Photodynamic/Photothermal Cancer Therapy.International journal of molecular sciences · 2022Article
- Polymethine dyes for PDT: recent advances and perspectives to drive future applications.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Review
- Charged groups on pyropheophorbide-based photosensitizers dictate uptake by tumor cells and photodynamic therapy efficacy.Journal of photochemistry and photobiology. B, Biology · 2022Article
- Potential of Cyanine Derived Dyes in Photodynamic Therapy.Pharmaceutics · 2021Review
- Chitosan as a Protective Matrix for the Squaraine Dye.Materials (Basel, Switzerland) · 2021Article
- Photocontrolled activation of small molecule cancer therapeutics.RSC medicinal chemistry · 2020Review
- Red and Near-Infrared Absorbing DicyanomethyleneSquaraine Cyanine Dyes: PhotophysicochemicalProperties and Anti-Tumor Photosensitizing Effects.Materials (Basel, Switzerland) · 2020Article
- Synthesis, Photochemical and In Vitro Cytotoxic Evaluation of New Iodinated Aminosquaraines as Potential Sensitizers for Photodynamic Therapy.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of ideal photosensitizers limits the clinicalapplication of photodynamic therapy (PDT). Here we report the PDT efficiency of dicyanomethylene substituted benzothiazole squaraine derivatives. This class of squaraine derivatives possess strong absorption and long excitation and emission wavelengths (ex/em, 685/720nm). They show negligible dark toxicity, but can generate singlet oxygen under irradiation resulting in the apoptosis and necrosis of cells (phototoxicity). Changing the side chains of these compounds greatly influences their albumin-binding rate, cellular uptake and their phototoxicity. One of the squaraine derivatives with two methyl butyrate side chains shows high PDT efficiency in a mouse subcutaneous xenograft model under the irradiation of a 690nm laser. These results show the great potential of dicyanomethylene substituted benzothiazole squaraines to be the leading compound of near-infrared photosensitizers in PDT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.