Evidence map›Paper›PMID 28811068›Full record

ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2017

A positron emission tomography study of the serotonergic system in relation to anxiety in depression.

Zafer Iscan, Gopalkumar Rakesh, Samantha Rossano, Jie Yang, Mengru Zhang, Jeffrey Miller, Gregory M Sullivan, Priya Sharma, Matthew McClure, Maria A Oquendo and 3 more

Open access · greenAbstract read
In one paragraph

Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Zafer IscanCentre for Cognition and Decision Making, National Research University, Higher School of Economics, Russian Federation; Cognitive Neuroimaging Unit, CEA DRF/Joliot Institute, INSERM, Université Paris-Sud, Université Paris-Saclay, NeuroSpin Center, 91191 Gif-sur-Yvette, France. Electronic address: zaferiscan@yahoo.com.
Gopalkumar RakeshDuke University Health System, Durham, NC, USA.
Samantha RossanoDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
Jie YangFamily, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Mengru ZhangApplied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
Jeffrey MillerNew York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY, USA.
Gregory M SullivanTonix Pharmaceuticals, Inc., 509 Madison Avenue Suite 306, New York, NY, USA.
Priya SharmaDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
Matthew McClureDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
Maria A OquendoNew York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY, USA.
J John MannNew York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY, USA.
Ramin V ParseyDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA; Radiology, Stony Brook University, Stony Brook, NY, USA.
Christine DeLorenzoDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA; New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY, USA.
Stony Brook University · USColumbia University · USApplied Mathematics (United States) · USDuke University Health System · USEloxx Pharmaceuticals (United States) · USUniversité Paris-Sud · FR

Funding

THE NEUROBIOLOGY OF SUICIDAL BEHAVIORP50MH062185 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2000 to 2009
$21.7M
Neurobiology of Depression and AntidepressantsR01MH040695 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI MANN, JOSEPH JOHN · 1986 to 2014
$7.1M
Biological Predictors of Response to AntidepressantsR01MH074813 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARSEY, RAMIN V. · 2006 to 2010
$2.3M
Characterization of a New Metabotropic Glutamate Receptor Subtype 5 PET LigandK01MH091354 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI DELORENZO, CHRISTINE · 2011 to 2014
$691k
NIMH NIH HHS K01 MH091354NIMH NIH HHS P50 MH062185NIMH NIH HHS R01 MH040695NIMH NIH HHS R01 MH074813
6 · The paper itself

Abstract

Symptoms of anxiety are highly comorbid with major depressive disorder (MDD) and are known to alter the course of the disease. To help elucidate the biological underpinnings of these prevalent disorders, we previously examined the relationship between components of anxiety (somatic, psychic and motoric) and serotonin 1A receptor (5-HT

Indexed as

Positron-Emission TomographyAdolescentAdultAnxietyBenzylaminesBrainBrain MappingCarbon RadioisotopesCohort StudiesComorbidityFemaleHumansMajor Depressive DisorderMaleMiddle AgedPiperazinesBenzylaminesCarbon RadioisotopesHTR1A protein, humanN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylaminePiperazinesPyridinesRadiopharmaceuticalsReceptor, Serotonin, 5-HT1ASerotoninSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanAnxietyDepressionPositron emission tomographySerotonin

Identifiers

PMID28811068
PMCPMC5623123
OpenAlexW2745514346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.