Evidence map›Paper›PMID 28811048›Full record

Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017

Receipt of Nephrology Care and Clinical Outcomes Among Veterans With Advanced CKD.

Enrica Fung, Tara I Chang, Glenn M Chertow, I-Chun Thomas, Steven M Asch, Manjula Kurella Tamura

Abstract readObservational Study
In one paragraph

Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Renin-angiotensin system blocker discontinuation and adverse outcomes in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Trends in Quality of Care for Patients with CKD in the United States.Clinical journal of the American Society of Nephrology : CJASN · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Enrica FungDivision of Nephrology, Stanford University School of Medicine, Palo Alto, CA. Electronic address: enricaf@gmail.com.
Tara I ChangDivision of Nephrology, Stanford University School of Medicine, Palo Alto, CA.
Glenn M ChertowDivision of Nephrology, Stanford University School of Medicine, Palo Alto, CA.
I-Chun ThomasDivision of Nephrology, Stanford University School of Medicine, Palo Alto, CA.
Steven M AschCenter for Innovation to Implementation, VA Palo Alto Health Care System, Palo Alto, CA.
Manjula Kurella TamuraDivision of Nephrology, Stanford University School of Medicine, Palo Alto, CA; Geriatric Research and Education Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA.
Stanford University · USVA Palo Alto Health Care System · USPalo Alto University · US

Funding

TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007357 · NIDDK · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW · 1986 to 2022
$4.8M
Mentoring Patient-Oriented Clinical Investigators in NephrologyK24DK085446 · NIDDK · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW · 2010 to 2022
$1.4M
Towards optimizing care for cardiovascular disease in chronic kidney diseaseK23DK095914 · NIDDK · STANFORD UNIVERSITY · PI CHANG, TARA I-HSIN · 2013 to 2017
$908k
Continuity of Care in Advanced Chronic Kidney DiseaseF32DK107111 · NIDDK · STANFORD UNIVERSITY · PI FUNG, ENRICA · 2015 to 2016
$125k
Understanding the Initiation of Maintentenance Dialysis among Older VeteransI01HX001262 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI KURELLA TAMURA, MANJULA · 2014 to 2020
–
HSRD VA I01 HX001262NIDDK NIH HHS F32 DK107111NIDDK NIH HHS K23 DK095914NIDDK NIH HHS K24 DK085446NIDDK NIH HHS T32 DK007357
6 · The paper itself

Abstract

backgroundClinical practice guidelines recommend referral to nephrology when estimated glomerular filtration rate (eGFR) decreases to <30mL/min/1.73m STUDY

designObservational cohort using landmark analysis. SETTINGS &

participantsA national cohort of veterans with advanced chronic kidney disease, defined as an outpatient eGFR≤30mL/min/1.73m PREDICTOR: Receipt and frequency of outpatient nephrology care over 12 months. OUTCOMES: Survival and progression to end-stage renal disease (ESRD; receipt of dialysis or kidney transplantation) were the primary outcomes. In addition, control of associated clinical parameters over 12 months were intermediate outcomes.

resultsOf 39,669 patients included in the cohort, 14,983 (37.8%) received nephrology care. Older age, heart failure, dementia, depression, and rapidly declining kidney function were independently associated with the absence of nephrology care. During a mean follow-up of 2.9 years, 14,719 (37.1%) patients died and 4,310 (10.9%) progressed to ESRD. In models adjusting for demographics, comorbid conditions, and trajectory of kidney function, nephrology care was associated with lower risk for death (HR, 0.88; 95% CI, 0.85-0.91), but higher risk for ESRD (HR, 1.48; 95% CI, 1.38-1.58). Among patients with clinical parameters outside guideline recommendations at cohort entry, a significantly higher adjusted proportion of patients who received nephrology care had improvement in control of hemoglobin, potassium, albumin, calcium, and phosphorus concentrations compared with those who did not receive nephrology care. LIMITATIONS: May not be generalizable to nonveterans.

conclusionsAmong patients with advanced chronic kidney disease, nephrology care was associated with lower mortality, but was not associated with lower risk for progression to ESRD.

Indexed as

NephrologyReferral and ConsultationVeteransAdultAgedAge FactorsCohort StudiesComorbidityDementiaDepressionDisease ProgressionFemaleGlomerular Filtration RateHeart FailureHumansKidney Failure, ChronicChronic kidney disease (CKD)CKD progressiondelivery of health caredisease trajectoryend-stage renal disease (ESRD)guideline-concordant careimmortal time biasintensity of carelandmark analysisnephrologynephrology carenephrology referral

Identifiers

PMID28811048
PMCPMC5651183
OpenAlexW2747633123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.