Evidence map›Paper›PMID 28810918›Full record

Trial reportJournal of orthopaedic surgery and research2017

Tranexamic acid reduces hidden blood loss in the treatment of intertrochanteric fractures with PFNA: a single-center randomized controlled trial.

Jinlai Lei, Binfei Zhang, Yuxuan Cong, Yan Zhuang, Xing Wei, Yahui Fu, Wei Wei, Pengfei Wang, Shiming Wen, Hai Huang and 4 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of orthopaedic surgery and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 13 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04488367 early_phase1unknown statusnot on this mapstarted 2020, after this paper: background citation

The Effects of the Timing of Tranexamic Acid Administration on Blood Loss in Hip Fractures.

TypeinterventionalSponsorCommunity Memorial Health SystemRan2020 to 2023Enrolled120ConditionsHip FracturesArmsTranexamic acid, Normal Saline
NCT04696224 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Comparative Use of Tranexamic Acid Intravenous and Topical Application in the Treatment of Intertrochanteric Fractures With Proximate Femoral Nail

TypeinterventionalSponsorUniversidade do Vale do SapucaiRan2020 to 2022Enrolled90ConditionsHemorrhage, Fracture FemurArmsTranexamic acid, Saline solution
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 13 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Efficacy and safety of Tranexamic acid use on postoperative blood transfusion in hip fracture patients- a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
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  4. Update on the efficacy and safety of intravenous tranexamic acid in hip fracture surgery: a systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023
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  11. Efficacy and Safety of Tranexamic Acid for Blood Salvage in Intertrochanteric Fracture Surgery: A Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
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  15. Tranexamic acid safely reduces hidden blood loss in patients undergoing intertrochanteric fracture surgery: a randomized controlled trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
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  17. [Application of intravenous injection of tranexamic acid combined with local use of tranexamic acid cocktail in intertrochanteric fracture fixation].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jinlai LeiDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Binfei ZhangDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Yuxuan CongDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Yan ZhuangDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China. lei7419@126.com.
Xing WeiDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Yahui FuDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Wei WeiDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Pengfei WangDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Shiming WenDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Hai HuangDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Hu WangDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Shuang HanDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Shuguang LiuDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China.
Kun ZhangDepartment of Orthopaedic Trauma, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, No 555, Youyi East Road, Xi'an, Shaanxi Province, China. hhyyzk@126.com.
Xi'an Honghui Hospital · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHidden blood loss is a major concern for patients undergoing hip surgery for intertrochanteric fracture. The objective of this study was to investigate whether tranexamic acid (TXA) could reduce postoperative hidden blood loss in patients undergoing hip surgery for intertrochanteric fracture.

methodsA total of 77 patients with intertrochanteric fracture were enrolled in this randomized controlled study. Patients received either 200 mL (1 g) of TXA (n = 37) or normal-saline (NS) (n = 40) i.v. before hip surgery using proximal femoral nail anti-rotation (PFNA). Hemoglobin and hematocrit levels were measured preoperatively and postoperatively at day 1 and 3. Visible and hidden blood loss volumes were calculated at postoperative day 3.

resultsOn postoperative day 3, the transfusion rate was significantly lower in the TXA group compared to the NS group, although mean hemoglobin and hematocrit levels were not significantly different between the two groups. However, the estimated hidden blood loss volume (210.09 ± 202.14 mL vs. 359.35 ± 290.12 mL; P < 0.05) and total blood loss volume (279.35 ± 209.11 mL vs. 417.89 ± 289.56 mL; P < 0.05) were significantly less in the TXA group compared to the NS group, respectively.

conclusionTXA significantly reduced postoperative hidden blood loss in patients with intertrochanteric fracture who underwent PFNA. (Registration number: ChiCTR-INR-16008134).

Indexed as

AgedAged, 80 and overAntifibrinolytic AgentsFemaleFracture Fixation, InternalHip FracturesHumansMalePostoperative HemorrhageProspective StudiesTranexamic AcidAntifibrinolytic AgentsTranexamic AcidFractureHidden blood lossIntertrochanteric femoraPFNARandomized controlled trialTranexamic acid

Identifiers

PMID28810918
PMCPMC5558747
OpenAlexW2746704603

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.