ArticleBMC genetics2017
Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats.
Article in BMC genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Effects of Parental Dietary Restriction on Offspring Fitness inNutrients · 2023Article
- Renin-Angiotensin System in Liver Metabolism: Gender Differences and Role of Incretins.Metabolites · 2022Review
- Protein restriction during lactation causes transgenerational metabolic dysfunction in adult rat offspring.Frontiers in nutrition · 2022Article
- Crocin-I Protects Against High-Fat Diet-Induced ObesityFrontiers in pharmacology · 2022Article
- Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations.International journal of molecular sciences · 2021Article
- Long-term effects of pro-opiomelanocortin methylation induced in food-restricted dams on metabolic phenotypes in male rat offspring.Obstetrics & gynecology science · 2020Article
- Nutrigenomics in livestock-recent advances.Journal of applied genetics · 2020Review
- Epigenetic Regulation by Dietary Restriction: Part II.Conditioning medicine · 2019Article
- Hepatic DNA methylation and expression profiles under prenatal restricted diet in three generations of female rat fetuses.PloS one · 2019Article
- Nutriepigenetics and cardiovascular disease.Current opinion in clinical nutrition and metabolic care · 2018Review
- Transgenerational effects of prenatal restricted diet on gene expression and histone modifications in the rat.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUndernutrition is an increasingly common problem. Insufficient calorie intake and nutrient deficiencies during pregnancy may have an impact not only on the mother, but may also alter metabolism in the infant. In this study, we have applied a calorie-restricted diet during gestation and examined its effect on hepatic Fasn mRNA and DNA methylation profiles in rats and their female progeny. The body composition and blood lipid profiles were also evaluated in both generations.
resultsThe results showed that the investigated diet regimen exerted a greater effect on the dams than on the offspring. We found that, in the calorie-restricted group, the transcript level of the Fasn gene in the liver increased in the mothers, while in the progeny it was only slightly enhanced. The implemented diet altered lipid profile in the dams by decreasing total cholesterol, HDL, and TG levels. An increase in LDL was noted in the offspring. No change in DNA methylation profile was observed in response to the calorie-restricted diet.
conclusionsCalorie restriction during pregnancy modified the hepatic Fasn mRNA transcript level and altered the blood cholesterol concentrations in dams, but there were no such effects in their four-week-old offspring. The examined dietary regimen had no effect on DNA methylation of the Fasn 5'-flanking region in the rat liver.
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