ArticleBMC genomics2017
Genome-wide analysis of basic helix-loop-helix (bHLH) transcription factors in Brachypodium distachyon.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 149 citations in OpenAlex.
- Recent progress in unraveling the molecular mechanisms of anthocyanin biosynthesis and regulation in tomato.Horticulture research · 2026Article
- Identification, characterization, and expression profiling of the bHLH gene family in Beta vulgaris.BMC plant biology · 2025Article
- Pangenome and pantranscriptome as the new reference for gene-family characterization: A case study of basic helix-loop-helix (bHLH) genes in barley.Plant communications · 2025Article
- Analysis of growth variations and expression patterns of auxin response factor gene family inFrontiers in plant science · 2025Article
- Genome-Wide Identification of Basic Helix-Loop-Helix (International journal of molecular sciences · 2024Article
- Transcriptome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2024Article
- Basic helix-loop-helix (bHLH) gene family in rye (Secale cereale L.): genome-wide identification, phylogeny, evolutionary expansion and expression analyses.BMC genomics · 2024Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis of Barley bHLH Transcription Factors and the Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Review
- Genome-Wide Identification and Expression Analysis of the bHLH Transcription Factor Family and Its Response to Abiotic Stress in Mongolian Oak (Current issues in molecular biology · 2023Article
- Article
- Article
- Genome-Wide Identification of Wheat KNOX Gene Family and Functional Characterization ofInternational journal of molecular sciences · 2022Article
- Adaptation insights from comparative transcriptome analysis of two Opisthopappus species in the Taihang mountains.BMC genomics · 2022Article
- Genome-wide analysis of basic helix-loop-helix (bHLH) transcription factors in Aquilaria sinensis.Scientific reports · 2022Article
- Genome-wide identification and characterization of PdbHLH transcription factors related to anthocyanin biosynthesis in colored-leaf poplar (Populus deltoids).BMC genomics · 2022Article
- CabHLH79 Acts Upstream ofInternational journal of molecular sciences · 2022Article
- Transcriptome-wide characterization of bHLH transcription factor genes inFrontiers in plant science · 2022Article
- Genome-Wide Identification and Characterization of MelonPlants (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a superfamily of transcription factors (TFs), the basic helix-loop-helix (bHLH) proteins have been characterized functionally in many plants with a vital role in the regulation of diverse biological processes including growth, development, response to various stresses, and so on. However, no systemic analysis of the bHLH TFs has been reported in Brachypodium distachyon, an emerging model plant in Poaceae.
resultsA total of 146 bHLH TFs were identified in the Brachypodium distachyon genome and classified into 24 subfamilies. BdbHLHs in the same subfamily share similar protein motifs and gene structures. Gene duplication events showed a close relationship to rice, maize and sorghum, and segment duplications might play a key role in the expansion of this gene family. The amino acid sequence of the bHLH domains were quite conservative, especially Leu-27 and Leu-54. Based on the predicted binding activities, the BdbHLHs were divided into DNA binding and non-DNA binding types. According to the gene ontology (GO) analysis, BdbHLHs were speculated to function in homodimer or heterodimer manner. By integrating the available high throughput data in public database and results of quantitative RT-PCR, we found the expression profiles of BdbHLHs were different, implying their differentiated functions.
conclusionOne hundred fourty-six BdbHLHs were identified and their conserved domains, sequence features, phylogenetic relationship, chromosomal distribution, GO annotations, gene structures, gene duplication and expression profiles were investigated. Our findings lay a foundation for further evolutionary and functional elucidation of BdbHLH genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.