ArticleExperimental and therapeutic medicine2017
Alterations in biomechanical properties and microstructure of colon wall in early-stage experimental colitis.
Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Mechanical experimentation of the gastrointestinal tract: a systematic review.Biomechanics and modeling in mechanobiology · 2024Pooled it
- A biomechanical model of inflammation-driven colon hypertrophy and dysmotility: Application to Gulf War Illness.Journal of the mechanical behavior of biomedical materials · 2026Article
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Differential pathological changes in colon microenvironments in acute and chronic mouse models of inflammatory bowel disease.Animal cells and systems · 2025Article
- The resolvin D2 and omega-3 polyunsaturated fatty acid as a new possible therapeutic approach for inflammatory bowel diseases.Scientific reports · 2024Article
- Mechanobiological considerations in colorectal stapling: Implications for technology development.Surgery open science · 2023Review
- Layer-Specific Damage Modeling of Porcine Large Intestine under Biaxial Tension.Bioengineering (Basel, Switzerland) · 2022Article
- Roasted garlic protects against leaky gut syndrome in dextran sodium sulfate-induced colitis mice.Food science and biotechnology · 2022Article
- Differential diagnosis of acute and chronic colitis in mice by optical coherence tomography.Quantitative imaging in medicine and surgery · 2022Article
- Predicting the micromechanics of embedded nerve fibers using a novel three-layered model of mouse distal colon and rectum.Journal of the mechanical behavior of biomedical materials · 2022Article
- Computational Modeling of Mouse Colorectum Capturing Longitudinal and Through-thickness Biomechanical Heterogeneity.Journal of the mechanical behavior of biomedical materials · 2021Article
- The Macro- and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods.Bioengineering (Basel, Switzerland) · 2020Review
- The Macro- and Micro-Mechanics of the Colon and Rectum I: Experimental Evidence.Bioengineering (Basel, Switzerland) · 2020Review
- Histological and ultrastructural changes of the colon in dextran sodium sulfate-induced mouse colitis.Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the current study was to investigate the effects of early-stage dextran sodium sulfate (DSS)-induced mouse colitis on the biomechanical properties and microstructure of colon walls. In the present study, colitis was induced in 8-week-old mice by the oral administration of DSS, and then 10 control and 10 experimental colitis samples were harvested. Uniaxial tensile tests were performed to measure the ultimate tensile strength and ultimate stretches of colon tissues. In addition, histological investigations were performed to characterize changes in the microstructure of the colon wall following treatment. The results revealed that the ultimate tensile stresses were 232±33 and 183±25 kPa for the control and DSS groups, respectively (P=0.001). Ultimate stretches at rupture for the control and DSS groups were 1.43±0.04 and 1.51±0.06, respectively (P=0.006). However, there was no statistically significant difference in tissue stiffness between the two groups. Histological analysis demonstrated high numbers of inflammatory cells infiltrated into the stroma in the DSS group, leading to significant submucosa edema. Hyperplasia was also identified in the DSS-treated submucosa, causing a disorganized microstructure within the colon wall. Furthermore, a large number of collagen fibers in the DSS-treated muscular layer were disrupted, and fiber bundles were thinner when compared with the control group. In conclusion, early-stage experimental colitis alters the mechanical properties and microstructural characteristics of the colon walls, further contributing to tissue remodeling in the pathological process.
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