ArticleExperimental and therapeutic medicine2017
MicroRNA-130a is highly expressed in the esophageal mucosa of achalasia patients.
Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Focus on Achalasia in the Omics Era.International journal of molecular sciences · 2024Review
- Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting theInternational journal of molecular sciences · 2022Article
- The progress of research into pseudophosphatases.Frontiers in public health · 2022Review
- The Roles of Pseudophosphatases in Disease.International journal of molecular sciences · 2021Review
- Identification of differentially expressed microRNAs in primary esophageal achalasia by next-generation sequencing.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- Upregulation of circulating miR130a is correlated with development of Barrett's esophagus and esophageal adenocarcinoma.OncoTargets and therapy · 2019Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to assess their alteration following POEM. RNA was extracted from biopsy samples from middle esophageal mucosa and analyzed using a microarray. Differentially expressed miRs in achalasia patients compared with control samples were identified and analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Correlations between specific miR expression levels and the patients' clinical background were also investigated. In addition, alterations of selected miR expression levels before and after POEM were analyzed. The results of RT-qPCR analysis demonstrated that the miR-130a expression levels were significantly higher in patients with achalasia (P<0.0001). In addition, miR-130a expression was significantly correlated with male sex and smoking history in patients with achalasia. However, no significant change in miR-130a expression was observed between before and after POEM. In conclusion, miR-130a is highly expressed in the esophageal mucosa of patients with achalasia and may be a biomarker of esophageal achalasia.
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