ArticleTranslational psychiatry2017
Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766).
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic factors influencing a neurobiological substrate for psychiatric disorders.Translational psychiatry · 2021Pooled it
- Genetic Markers of ADHD-Related Variations in Intracranial Volume.The American journal of psychiatry · 2019Pooled it
- The Relationship Between Polygenic Risk of Depression and Regional Brain Atrophy in Older Adults.International journal of geriatric psychiatry · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities.Brain imaging and behavior · 2024Article
- SCAMPI: A scalable statistical framework for genome-wide interaction testing harnessing cross-trait correlations.bioRxiv : the preprint server for biology · 2024Article
- Investigating the shared genetic architecture between depression and subcortical volumes.Nature communications · 2024Article
- Investigating the genetic relationship of intracranial and subcortical brain volumes with depression and other psychiatric disorders.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mendelian randomization studies of depression: evidence, opportunities, and challenges.Annals of general psychiatry · 2023Review
- Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities.Research square · 2023Article
- Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.PLoS genetics · 2022Article
- Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.Human brain mapping · 2022Review
- Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.Molecular psychiatry · 2021Article
- The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.Nature communications · 2020Review
- Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.Nature genetics · 2019Article
- Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity.Scientific reports · 2019Article
- Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa.Molecular neurobiology · 2019Article
- Hippocampal Volume as a Putative Marker of Resilience or Compensation to Minor Depressive Symptoms in a Nonclinical Sample.Frontiers in psychiatry · 2019Article
- Evidence for association between familial bipolar risk and ventral striatal volume.Journal of affective disorders · 2018Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Major depressive disorder (MDD) is a heritable and highly debilitating condition. It is commonly associated with subcortical volumetric abnormalities, the most replicated of these being reduced hippocampal volume. Using the most recent published data from Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium's genome-wide association study of regional brain volume, we sought to test whether there is shared genetic architecture between seven subcortical brain volumes and intracranial volume (ICV) and MDD. We explored this using linkage disequilibrium score regression, polygenic risk scoring (PRS) techniques, Mendelian randomisation (MR) analysis and BUHMBOX. Utilising summary statistics from ENIGMA and Psychiatric Genomics Consortium, we demonstrated that hippocampal volume was positively genetically correlated with MDD (r
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