Evidence map›Paper›PMID 28809546›Full record

ArticleBiochemistry2017

Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase.

Xinyan Zhang, Kenneth W Bayles, Sorin Luca

Open access · bronzeAbstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Journal of bacteriology · 2025
    Article
  2. Review
  3. Article
  4. Mutations in thebioRxiv : the preprint server for biology · 2024
    Article
  5. Review
  6. Delineating the Role of theFrontiers in microbiology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xinyan ZhangDepartment of Pharmaceutical Sciences and ‡Department of Pathology & Microbiology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5900, United States.
Kenneth W BaylesDepartment of Pharmaceutical Sciences and ‡Department of Pathology & Microbiology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5900, United States.ORCID 0000-0001-9521-3540
Sorin LucaDepartment of Pharmaceutical Sciences and ‡Department of Pathology & Microbiology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5900, United States.
Nebraska Medical Center · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2009 to 2023
$32.1M
The molecular control of bacterial autolysisR01AI038901 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2003 to 2012
$3.1M
The molecular control of bacterial programmed cell deathR01AI125589 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2016 to 2020
$1.9M
NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI038901NIAID NIH HHS R01 AI125589
6 · The paper itself

Abstract

Recent studies have revealed an important role for the Staphylococcus aureus CidC enzyme in cell death during the stationary phase and in biofilm development and have contributed to our understanding of the metabolic processes that are important in the induction of bacterial programmed cell death (PCD). To gain more insight into the characteristics of this enzyme, we performed an in-depth biochemical and biophysical analysis of its catalytic properties. In vitro experiments show that this flavoprotein catalyzes the oxidative decarboxylation of pyruvate to acetate and carbon dioxide. CidC efficiently reduces menadione, but not CoenzymeQ

Indexed as

ApoptosisBacterial ProteinsCell MembraneCoenzymesGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicHydrogen-Ion ConcentrationOxidoreductasesPhospholipidsStaphylococcus aureusSubstrate SpecificityBacterial ProteinsCoenzymesOxidoreductasesPhospholipids

Identifiers

PMID28809546
PMCPMC5853648
OpenAlexW2746841223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.