ArticleThe journal of headache and pain2017
Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study.
Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- Hypoperfusion of periaqueductal gray as an imaging biomarker in chronic migraine beyond diagnosis: A 3D pseudocontinuous arterial spin labeling MR imaging.Brain and behavior · 2024Article
- Differences in Neuropathology between Nitroglycerin-Induced Mouse Models of Episodic and Chronic Migraine.International journal of molecular sciences · 2024Article
- Contralateral acupuncture for migraine without aura: a randomized trial protocol with multimodal MRI.Frontiers in neuroscience · 2024Article
- Review
- Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma.Journal of central nervous system disease · 2023Review
- The role of the brainstem in sleep disturbances and chronic pain of Gulf War and Iraq/Afghanistan veterans.Frontiers in molecular neuroscience · 2023Article
- Neuroimaging for differential diagnosis of transient neurological attacks.Brain and behavior · 2022Review
- The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence.Brain sciences · 2022Review
- Cortical metabolic and structural differences in patients with chronic migraine. An exploratoryThe journal of headache and pain · 2021Article
- From transformation to chronification of migraine: pathophysiological and clinical aspects.The journal of headache and pain · 2020Review
- Toward a Multimodal Framework of Brainstem Pain-Modulation Circuits in Migraine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Volume alterations of brainstem subregions in migraine with aura.NeuroImage. Clinical · 2019Article
- Comparison of gray matter volume between migraine and "strict-criteria" tension-type headache.The journal of headache and pain · 2018Article
- Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis.The journal of headache and pain · 2017Article
- Article
- Cortical mechanisms in migraine.Molecular painArticle
- Review
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe periaqueductal gray (PAG) dysfunction was recognized in migraine, and the nonspecific PAG lesions were also observed in episodic migraine (EM) recently. However, the PAG volume change was not totally detected in EM up to now. Herein, the aim of this study was to investigate altered PAG volume in EM patients based on high resolution brain structural image.
methodsThe brain structural images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) on 3.0 T MR system. PAG template was created based on the ICBM152 gray matter template using MRIcron, and the individual PAG was created by applying the deformation field to the PAG template after structural image segment. One-way analysis of covariance, partial correlation analysis and Receiver operating characteristics (ROC) curve were applied.
resultsEM had a larger PAG volume (0.35 ± 0.02 ml) than that (0.32 ± 0.02 ml) of NC (P = 0.017). The PAG volume of CM (0.33 ± 0.02 ml) was negatively related to the VAS score (P = 0.03). ROC analysis demonstrated that PAG volume has higher diagnostic efficacy (AUC, 0.731; Sensitivity, 0.556; Specificity, 0.889) for NC vs. EM compared with that NC vs. CM (AUC, 0.634; Sensitivity, 0.438; Specificity, 0.833) and EM vs. CM (AUC, 0.618; Sensitivity, 0.813; Specificity, 0.556).
conclusionPAG volume expansion may be the direct impairment evidence on the brain in EM, and could be considered as a diagnostic and evaluated imaging biomarker in migraine.
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