Evidence map›Paper›PMID 28808862›Full record

ArticleEnvironmental science and pollution research international2017

A pilot study comparing T-regulatory cell function among healthy children in different areas of Gansu, China.

Panhong Gou, Xiaoru Chang, Zhonghui Ye, Yueli Yao, Patton Khuu Nguyen, Sally Katharine Hammond, Junling Wang, Sa Liu

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Panhong GouDepartment of Toxicology, School of Public Health, Lanzhou University, No 199 Donggang West Road, Lanzhou, 730000, China.
Xiaoru ChangDepartment of Toxicology, School of Public Health, Lanzhou University, No 199 Donggang West Road, Lanzhou, 730000, China.
Zhonghui YeDepartment of Toxicology, School of Public Health, Lanzhou University, No 199 Donggang West Road, Lanzhou, 730000, China.
Yueli YaoDepartment of Toxicology, School of Public Health, Lanzhou University, No 199 Donggang West Road, Lanzhou, 730000, China.
Patton Khuu NguyenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall, #7360, Berkeley, CA, 94720-7360, USA.
Sally Katharine HammondDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall, #7360, Berkeley, CA, 94720-7360, USA.
Junling WangDepartment of Toxicology, School of Public Health, Lanzhou University, No 199 Donggang West Road, Lanzhou, 730000, China. wangjl@lzu.edu.cn.
Sa LiuDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall, #7360, Berkeley, CA, 94720-7360, USA. saliu@berkeley.edu.
Lanzhou University · CNUniversity of California, Berkeley · USBerkeley Public Health Division · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune system is critical to protecting human health from toxic substances. Our previously published research had found an important link between polycyclic aromatic hydrocarbons (PAHs) in ambient air and changes at the DNA level in immune cells that led to impaired function of regulatory T (Treg) cells in children living in California, USA. But molecular and cellular pathways of these changes remain unclear. The present study aims to explore whether exposure to PAHs leads to changes in Treg cells functions of children living in Gansu, China, where ambient air pollution levels are much higher than those in California, and to explore potential mechanisms of PAH-induced immunological dysfunctions. Air pollutions in Lanzhou and Lintao, Gansu Province, were measured from December 2015 to June 2016. Healthy children were recruited from both cities and enrolled in this pilot study. Demographic information was collected by questionnaires. Blood samples were collected. Peripheral blood Treg cells were analyzed for Treg cells percentage by flow cytometry. Gene expression of forkhead box transcription factor 3 (Foxp3), transforming growth factor-β (TGF-β), and interleukin 35 (IL35) were examined by reverse transcription-polymerase chain reaction (RT-PCR). The results indicated PAH concentration (as sum of 16 PAHs) in Lintao was over two times higher than that was in Lanzhou (707 vs. 326 ng/m

Indexed as

Air PollutantsCaliforniaChildChinaCitiesFemaleFlow CytometryForkhead Transcription FactorsHumansMalePilot ProjectsPolycyclic Aromatic HydrocarbonsT-Lymphocytes, RegulatoryAir PollutantsForkhead Transcription FactorsPolycyclic Aromatic HydrocarbonsAir pollutionCytokineImmune systemTreg cells

Identifiers

PMID28808862
OpenAlexW2749645144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.