Observational studyChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2017
Presentation and symptom interval in children with central nervous system tumors. A single-center experience.
Observational study in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Delay in the diagnosis of paediatric brain tumours: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Pooled it
- Bridging pediatric and adult neuro-oncology: Insights into adolescents and young adults (AYA) central nervous system tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Impact of the COVID-19 pandemic on referral practices for pediatric central nervous system tumors: A Danish National Comparative Cohort Study.Neuro-oncology practice · 2025Article
- Development of Functional Abilities Assessment in Paediatric Oncology (FAAP-O) Scale for Children and Adolescents Affected by Cancer.Children (Basel, Switzerland) · 2025Article
- Impact of the COVID-19 pandemic on diagnosis and management of new brain tumours in children and young people (aged < 16 years old) in the UK.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Observational
- Early ophthalmological tumour signs and diagnostic interval in children with brain tumours.Eye (London, England) · 2025Article
- Hjernetegn.dk-The Danish Central Nervous System Tumor Awareness Initiative Digital Decision Support Tool: Design and Implementation Report.JMIR medical informatics · 2024Article
- Neurosurgical treatment of pediatric brain tumors - results from a single center multidisciplinary setup.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Total diagnostic interval in children with brain tumours in a middle-income country: national experience from Serbia.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- The effects of educational interventions and the COVID-19 pandemic on the time to diagnosis in pediatric patients with primary central nervous system tumors.Neuro-oncology practice · 2023Article
- Article
- Musculoskeletal misdiagnoses in children with brain tumors: A nationwide, multicenter case-control study.PloS one · 2023Article
- Ophthalmological Findings in Youths With a Newly Diagnosed Brain Tumor.JAMA ophthalmology · 2022Article
- Presenting symptoms and time to diagnosis for Pediatric Central Nervous System Tumors in Qatar: a report from Pediatric Neuro-Oncology Service in Qatar.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- The Role of Time as a Prognostic Factor in Pediatric Brain Tumors: a Multivariate Survival Analysis.Pathology oncology research : POR · 2020Article
- Time to diagnosis and clinical characteristics in pediatric brain tumor patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Chronic vomiting in children: Etiology, diagnosis, and management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.Journal of neuro-oncology · 2020Article
- The Management of Childhood Intracranial Tumours and the Role of the Ophthalmologist.Neuro-ophthalmology (Aeolus Press) · 2019Article
- Social determinants of health affecting treatment of pediatric brain tumors.Journal of neurosurgery. Pediatrics · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to describe the symptoms and signs of central nervous system (CNS) tumors in a pediatric population and to assess the time interval between the onset of the disease and the time of the diagnosis.
methodsA retrospective observational study was conducted at our Oncology Pediatric Unit between January 2000 and November 2011. We included 75 children between 5 months and 16 years (mean age of 7.8 ± 4.7 years), with male to female ratio of 3:2. The tumor localization was supratentorial in 51% of cases, and the most frequent histological type was low-grade astrocytoma (48%).
resultsPresenting symptoms were headache (31%), vomiting (31%), seizures (21%), and behavioral change (11%). The most common symptoms at diagnosis were headache (51%), vomiting (51%), visual difficulties (37%), seizures (24%), and behavioral change (21%). By the time of diagnosis, neurologic examination was altered in 68% of our patients. Vomiting (44%) and behavioral change (44%) were the most frequent symptoms in children under 4 years of age, headache (61%) and vomiting (54%) in children older than 4 years. The median interval between symptoms' onset and diagnosis was 4 weeks (range 0 to 314 weeks). A longer symptom interval was associated with younger age, infratentorial localization and low-grade tumors. The differences in symptom intervals between the different age, location, and grade groups were not statistically significant. Survival probability was influenced by tumor grade but not by diagnostic delay or age of the child.
conclusionsHeadache and vomiting are the earliest and commonest symptoms in children with brain tumors. Visual symptoms and signs and behavioral change are often present. Abnormalities in neurological examination are reported in most of the children. Intracranial hypertension symptoms suggest the need for a neurological clinical examination and an ophthalmological assessment.
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