ArticleHeliyon2017
Human serum albumin and oxidative stress in preeclamptic women and the mechanism of albumin for stress reduction.
Article in Heliyon, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Association between serum uric acid to albumin ratio and all-cause mortality in critically ill patients with sepsis: a retrospective study.BMC infectious diseases · 2025Article
- Antioxidant Properties of Albumin and Diseases Related to Obstetrics and Gynecology.Antioxidants (Basel, Switzerland) · 2025Review
- Association Between Neutrophil Percentage-to-Albumin Ratio and Depression in Middle-Aged and Elderly Adults: A National Study.Behavioural neurology · 2025Article
- Placental Origins of Preeclampsia: Insights from Multi-Omic Studies.International journal of molecular sciences · 2024Review
- Risk factors for preeclampsia in patients with chronic kidney disease primarily focused on stage 1 CKD. Are referred and registered patients alike?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Prediction model for severe maternal morbidity in pregnant women with hypertensive disorders of pregnancy.Pakistan journal of medical sciences · 2024Article
- The association of serum uric acid/albumin ratio with the development of coronary collateral circulation in patients with chronic total occluded coronary arteries.Journal of cardiovascular and thoracic research · 2023Article
- ALB-dNLR Score Predicts Mortality in Coronary Artery Disease Patients After Percutaneous Coronary Intervention.Frontiers in cardiovascular medicine · 2022Article
- Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia.Nagoya journal of medical science · 2021Article
- Review
- Grey Relational Analysis Combined With Network Pharmacology to Identify Antioxidant Components and Uncover Its Mechanism From Moutan Cortex.Frontiers in pharmacology · 2021Article
- Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis.Biomedical reports · 2020Article
- Establishment and assessment of a nomogram for predicting adverse outcomes of preterm preeclampsia.The Journal of international medical research · 2020Article
- Glycated albumin in pregnancy: reference intervals establishment and its predictive value in adverse pregnancy outcomes.BMC pregnancy and childbirth · 2020Article
- The association between albumin-dNLR score and disease activity in patients with rheumatoid arthritis.Journal of clinical laboratory analysis · 2019Article
- The necessity to use selective NADPH oxidase inhibitors.Journal of anesthesia · 2018Article
- Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols.Journal of inflammation research · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe present study to address one of the mechanisms in preeclampsia, examined whether levels of oxidative stress, human serum albumin, and endothelial function correlate in pregnant women and whether human serum albumin reduces levels of superoxide produced by NADPH oxidase activation in the human vascular smooth muscle cells. MATERIALS AND
methodsPregnant women with (Preeclampsia group, n = 33) and without preeclampsia (Normal group, n = 37) were recruited to determine levels of reactive oxygen species (serum diacron-reactive oxygen metabolite [d-ROM]), and the flow-mediated dilation (FMD). Human coronary arterial smooth muscle cells or omental arteries were subjected to evaluate isometric force recordings, levels of superoxide, western immunoblotting, and immunohistochemistry. The superoxide scavenging assay was also performed in a cell-free system. KEY
findingsWomen in the preeclampsia group demonstrated lower FMD and higher serum d-ROM values than those in the normal group. There were the inverse correlations between serum levels of d-ROM and the degree of FMD and between serum levels of albumin and those of d-ROM. D-glucose reduced the levcromakalim-induced dilation of human omental arteries, and it increased levels of superoxide and the recruitment of the NADPH oxidase subunit p47phox in human coronary arterial smooth muscle cells. Human serum albumin (0.05 to 0.5 g/dL) prevented these alterations whereas it exerted no superoxide scavenging effect. SIGNIFICANCE: Serum albumin relates to oxidative stress inversely, but to the endothelial function positively, in pregnant women. Human serum albumin appears to reduce oxidative stress via NADPH oxidase inhibition in the human vascular smooth muscle, indicating that the serum level may be a critical determinant of vascular oxidative stress in some human diseases.
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Registered trials
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