Evidence map›Paper›PMID 28808688›Full record

ArticlemSphere

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in

Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R Bezerra, Laura Carreto, Gabriela R Moura, Mónica Bayés and 5 more

Open access · goldAbstract read
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 55 citations in OpenAlex.

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  12. RSC chemical biology · 2021
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  15. Critical reviews in microbiology · 2021
    Review
  16. Review
  17. Myrtle Seeds (ACS omega · 2019
    Article
  18. Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 7 countries.

Tobias WeilDepartment of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.
Rodrigo SantamaríaDepartment of Computer Science, University of Salamanca, Salamanca, Spain.
Wanseon LeeEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
Johan RungEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
Noemi TocciResearch and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy.
Darren AbbeyDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Ana R BezerraDepartment of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.
Laura CarretoDepartment of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.
Gabriela R MouraDepartment of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.
Mónica BayésCentro Nacional de Análisis Genómico, Parc Científic, Barcelona, Spain.
Ivo G GutCentro Nacional de Análisis Genómico, Parc Científic, Barcelona, Spain.
Attila Csikasz-NagyResearch and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy.
Duccio CavalieriResearch and Innovation Centre, Fondazione E. Mach, San Michele All'Adige, Italy.
Judith BermanDepartment of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel.
Manuel A S SantosDepartment of Medical Sciences & Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal.
University of Aveiro · PTCentro Nacional de Análisis Genómico · ESFondazione Edmund Mach · ITKing's College London · GBScience for Life Laboratory · SETel Aviv University · ILUniversidad de Salamanca · ESUniversity of Minnesota · USWellcome Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen

Indexed as

aneuploidyCandida albicanscodon ambiguitydrug resistance evolutionfluconazoleLOHphenotypic variabilityprotein mistranslation

Identifiers

PMID28808688
PMCPMC5549176
OpenAlexW2743737770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.