ArticleNeuroImage. Clinical2017
A novel method of quantifying brain atrophy associated with age-related hearing loss.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Hearing loss and dementia: radiologic and biomolecular basis of their shared characteristics. A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study.JAMA network open · 2025Article
- Hearing Loss and Alzheimer Disease.Current topics in behavioral neurosciences · 2025Review
- Hearing Function Moderates Age-Related Differences in Brain Morphometry in the HCP Aging Cohort.Human brain mapping · 2024Article
- Alterations of Excitation-Inhibition Balance and Brain Network Dynamics Support Sensory Deprivation Theory in Presbycusis.Human brain mapping · 2024Article
- Hearing function moderates age-related changes in brain morphometry in the HCP Aging cohort.bioRxiv : the preprint server for biology · 2024Article
- Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.PloS one · 2024Article
- Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Degree centrality and functional connections in presbycusis with and without cognitive impairments.Brain imaging and behavior · 2022Article
- Considering hearing loss as a modifiable risk factor for dementia.Expert review of neurotherapeutics · 2022Article
- Aberrant brain functional network strength related to cognitive impairment in age-related hearing loss.Frontiers in neurology · 2022Article
- Cytoarchitectonic Maps of the Human Metathalamus in 3D Space.Frontiers in neuroanatomy · 2022Article
- No association between age-related hearing loss and brain age derived from structural neuroimaging data.Neuroimage. Reports · 2021Article
- Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population-Based Study.The Laryngoscope · 2021Article
- The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid.The Laryngoscope · 2021Article
- Aging Brain and Hearing: A Mini-Review.Frontiers in aging neuroscience · 2021Review
- Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review.Frontiers in aging neuroscience · 2021Article
- Neuroanatomical changes associated with age-related hearing loss and listening effort.Brain structure & function · 2020Article
- Visual short-term memory binding deficit with age-related hearing loss in cognitively normal older adults.Scientific reports · 2019Article
- Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study.Aging · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of evidence has shown that a relationship between age-related hearing loss and structural brain changes exists. However, a method to measure brain atrophy associated with hearing loss from a single MRI study (i.e. without an interval study) that produces an independently interpretable output does not. Such a method would be beneficial for studying patterns of structural brain changes on a large scale. Here, we introduce our method for this. Audiometric evaluations and mini-mental state exams were obtained in 34 subjects over the age of 80 who have had brain MRIs in the past 6 years. CSF and parenchymal brain volumes (whole brain and by lobe) were obtained through a novel, fully automated algorithm. Atrophy was calculated by taking the ratio of CSF to parenchyma. High frequency hearing loss was associated with disproportional temporal lobe atrophy relative to whole brain atrophy independent of age (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.