Evidence map›Paper›PMID 28808498›Full record

ReviewOxidative medicine and cellular longevity2017

Functional, Cellular, and Molecular Remodeling of the Heart under Influence of Oxidative Cigarette Tobacco Smoke.

Abdullah Kaplan, Emna Abidi, Rana Ghali, George W Booz, Firas Kobeissy, Fouad A Zouein

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Lasting consequences of cigarette smoking on the heart.Acta physiologica (Oxford, England) · 2024
    Article
  10. Article
  11. Optimisation of anFrontiers in toxicology · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Exercise Training Attenuates Cirrhotic Cardiomyopathy.Journal of cardiovascular translational research · 2021
    Article
  20. Subtle right ventricular dysfunction in asymptomatic chronic heavy cigarette smokers: a speckle tracking case-control study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Abdullah KaplanDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.
Emna AbidiDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.ORCID 0000-0002-6054-1840
Rana GhaliDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.
George W BoozDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center School of Medicine, Jackson, MS, USA.ORCID 0000-0003-1478-9615
Firas KobeissyDepartment of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine, Beirut, Lebanon.ORCID 0000-0002-5008-6944
Fouad A ZoueinDepartment of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.ORCID 0000-0003-4451-804X
American University of Beirut · LBUniversity of Mississippi Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Passive and active chronic cigarette smoking (CS) remains an international epidemic and a key risk factor for cardiovascular disease (CVD) development. CS-induced cardiac damage is divided into two major and interchangeable mechanisms: (1) direct adverse effects on the myocardium causing smoking cardiomyopathy and (2) indirect effects on the myocardium by fueling comorbidities such as atherosclerotic syndromes and hypertension that eventually damage and remodel the heart. To date, our understanding of cardiac remodeling following acute and chronic smoking exposure is not well elucidated. This manuscript presents for the first time the RIMD (oxidative stress (R), inflammation (I), metabolic impairment (M), and cell death (D)) detrimental cycle concept as a major player in CS-induced CVD risks and direct cardiac injury. Breakthroughs and latest findings in the field with respect to structural, functional, cellular, and molecular cardiac remodeling following chronic smoking exposure are summarized. This review also touches the genetics/epigenetics of smoking as well as the smoker's paradox and highlights the most currently prominent pharmacological venues to mitigate CS-induced adverse cardiac remodeling.

Indexed as

Oxidative StressSmokeAnimalsAntioxidantsCardiovascular DiseasesHumansInflammationMyocardiumNicotianaReactive Oxygen SpeciesRisk FactorsVentricular RemodelingAntioxidantsReactive Oxygen SpeciesSmoke

Identifiers

PMID28808498
PMCPMC5541812
OpenAlexW2736638943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.