Evidence map›Paper›PMID 28808347›Full record

ArticleScientific reports2017

TaiNi: Maximizing research output whilst improving animals' welfare in neurophysiology experiments.

Zhou Jiang, John R Huxter, Stuart A Bowyer, Anthony J Blockeel, James Butler, Syed A Imtiaz, Keith A Wafford, Keith G Phillips, Mark D Tricklebank, Hugh M Marston and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Fabrication of Injectable Micro-Scale Opto-Electronically Transduced Electrodes (MOTEs) for Physiological Monitoring.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2020
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhou JiangDepartment of Electrical and Electronic Engineering, Imperial College London, London, UK.
John R HuxterEli Lilly and Company Limited, Windlesham, UK. huxter_john@network.lilly.com.
Stuart A BowyerDepartment of Electrical and Electronic Engineering, Imperial College London, London, UK.
Anthony J BlockeelEli Lilly and Company Limited, Windlesham, UK.
James ButlerEli Lilly and Company Limited, Windlesham, UK.
Syed A ImtiazDepartment of Electrical and Electronic Engineering, Imperial College London, London, UK.
Keith A WaffordEli Lilly and Company Limited, Windlesham, UK.
Keith G PhillipsEli Lilly and Company Limited, Windlesham, UK.
Mark D TricklebankDepartment of Neuroimaging Sciences, Institute of Psychiatry, Kings College London, London, UK.
Hugh M MarstonEli Lilly and Company Limited, Windlesham, UK.
Esther Rodriguez-VillegasDepartment of Electrical and Electronic Engineering, Imperial College London, London, UK. e.rodriguez@imperial.ac.uk.

Funding

National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C011203/1
6 · The paper itself

Abstract

Understanding brain function at the cell and circuit level requires representation of neuronal activity through multiple recording sites and at high sampling rates. Traditional tethered recording systems restrict movement and limit the environments suitable for testing, while existing wireless technology is still too heavy for extended recording in mice. Here we tested TaiNi, a novel ultra-lightweight (<2 g) low power wireless system allowing 72-hours of recording from 16 channels sampled at ~19.5 KHz (9.7 KHz bandwidth). We captured local field potentials and action-potentials while mice engaged in unrestricted behaviour in a variety of environments and while performing tasks. Data was synchronized to behaviour with sub-second precision. Comparisons with a state-of-the-art wireless system demonstrated a significant improvement in behaviour owing to reduced weight. Parallel recordings with a tethered system revealed similar spike detection and clustering. TaiNi represents a significant advance in both animal welfare in electrophysiological experiments, and the scope for continuously recording large amounts of data from small animals.

Indexed as

Action PotentialsAnimalsAnimal WelfareBehavior, AnimalBrainElectrophysiological PhenomenaElectrophysiologyFemaleMiceNeuronsNeurophysiologyWireless Technology

Identifiers

PMID28808347
PMCPMC5556067

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.