ArticleScientific reports2017
MicroRNA-214 modulates neural progenitor cell differentiation by targeting Quaking during cerebral cortex development.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Diverse roles of quaking in endothelial cell biology.Angiogenesis · 2025Review
- MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.iScience · 2024Article
- MicroRNA-495 Modulates Neuronal Layer Fate Determination by TargetingInternational journal of biological sciences · 2024Article
- MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line.Frontiers in cellular neuroscience · 2024Article
- Localization Pattern of Dispatched Homolog 2 (DISP2) in the Central and Enteric Nervous System.Journal of molecular neuroscience : MN · 2023Article
- Three-dimensional molecular architecture of mouse organogenesis.Nature communications · 2023Article
- Editorial: Molecular and cellular logic of cerebral cortex development, evolution, and disease.Frontiers in neuroanatomy · 2023Article
- Diagnosis and Drug Prediction of Parkinson's Disease Based on Immune-Related Genes.Journal of molecular neuroscience : MN · 2022Article
- A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development.Nature cell biology · 2022Article
- Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats.Biomedicines · 2022Article
- Translational control in cortical development.Frontiers in neuroanatomy · 2022Article
- MicroRNA-Based Diagnosis and Therapeutics for Vascular Cognitive Impairment and Dementia.Frontiers in neurology · 2022Review
- Evolving features of human cortical development and the emerging roles of non-coding RNAs in neural progenitor cell diversity and function.Cellular and molecular life sciences : CMLS · 2021Article
- Exosomal miR-214-3p as a potential novel biomarker for rhabdoid tumor of the kidney.Pediatric surgery international · 2021Article
- MicroRNA-214 in Health and Disease.Cells · 2021Review
- miRNA-Based Regulation of Alternative RNA Splicing in Metazoans.International journal of molecular sciences · 2021Review
- Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA.Scientific reports · 2021Article
- Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by RegulatingFrontiers in neuroscience · 2021Article
- Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p.Neurochemical research · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accurate generation of an appropriate number of different neuronal and glial subtypes is fundamental to normal brain functions and requires tightly orchestrated spatial and temporal developmental programmes to maintain the balance between the proliferation and the differentiation of neural progenitor cells. However, the molecular mechanism governing this process has not been fully elucidated. Here, we found that miR-214-3p was highly expressed in neural progenitor cells and dynamically regulated during neocortical development. Moreover, our in vivo and in vitro studies showed that miR-214 inhibited self-renewal of neural progenitor cells and promoted neurogenesis. In addition, after target screening, we identified miR-214 targets including Quaking (Qki) by binding the 3'- untranslated region (3'-UTR) of the Qki mRNA, which was specifically expressed in the progenitor cells of the proliferative ventricular zone as 3 Qki isoforms. Furthermore, overexpression and knockdown of Qki showed that the different isoforms of Qki had different functions in the regulation of neural progenitor cells differentiation. Moreover, overexpression of Qki could counteract the function of miR-214 in neurogenesis. Our results revealed that miR-214 maintains the balance between neural progenitor/stem cell proliferation and differentiation together with Quaking, its target gene.
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