Evidence map›Paper›PMID 28808328›Full record

ArticleScientific reports2017

Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.

Keun Ah Ryu, Bethany McGonnigal, Troy Moore, Tawnya Kargupta, Rock J Mancini, Aaron P Esser-Kahn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Keun Ah RyuDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Bethany McGonnigalDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Troy MooreDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Tawnya KarguptaDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Rock J ManciniDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.
Aaron P Esser-KahnDepartment of Chemistry, University of California, Irvine, Irvine, CA, 92697, USA. aesserka@uci.edu.ORCID 0000-0003-1273-0951
University of California, Irvine · US

Funding

Determining the Molecular Mechanism of Covalently Linked TLR AgonistsU01AI124286 · NIAID · UNIVERSITY OF CHICAGO · PI ESSER-KAHN, AARON P · 2016 to 2020
$3.2M
Directing The Immune System Via Polymeric Combinations of Molecular SignalsDP2AI112194 · NIAID · UNIVERSITY OF CHICAGO · PI ESSER-KAHN, AARON P · 2013 to 2013
$2.3M
NIAID NIH HHS DP2 AI112194NIAID NIH HHS U01 AI124286
6 · The paper itself

Abstract

The complexity of the immune system creates challenges in exploring its importance and robustness. To date, there have been few techniques developed to manipulate individual components of the immune system in an in vivo environment. Here we show a light-based dendritic cell (DC) activation allowing spatial and temporal control of immune activation in vivo. Additionally, we show time dependent changes in RNA profiles of the draining lymph node, suggesting a change in cell profile following DC migration and indicating that the cells migrating have been activated towards antigen presentation.

Indexed as

AnimalsAntigen PresentationCell MovementDendritic CellsImmunity, InnateLightLymph NodesLymphocyte ActivationMiceRNAToll-Like Receptor 2Toll-Like Receptor 6RNATlr2 protein, mouseTlr6 protein, mouseToll-Like Receptor 2Toll-Like Receptor 6

Identifiers

PMID28808328
PMCPMC5556111
OpenAlexW2949724898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.