ArticleScientific reports2017
Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Acute inorganic nitrate supplementation and the hypoxic ventilatory response in patients with obstructive sleep apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Article
- The Oxygen Cascade from Atmosphere to Mitochondria as a Tool to Understand the (Mal)adaptation to Hypoxia.International journal of molecular sciences · 2023Review
- Potential Neuromodulation of the Cardio-Renal Syndrome.Journal of clinical medicine · 2023Review
- The superior cervical ganglion is involved in chronic chemoreflex sensitization during recovery from acute lung injury.Frontiers in physiology · 2023Article
- Chronic intermittent hypoxia promotes glomerular hyperfiltration and potentiates hypoxia-evoked decreases in renal perfusion and POFrontiers in physiology · 2023Article
- Role of Peripheral Chemoreceptors on Enhanced Central Chemoreflex Drive in Nonischemic Heart Failure.Advances in experimental medicine and biology · 2023Article
- Peripheral chemoreflex modulation of renal hemodynamics and renal tissue PO2 in chronic heart failure with reduced ejection fraction.Frontiers in physiology · 2022Article
- Contribution of Peripheral Chemoreceptors to Exercise Intolerance in Heart Failure.Frontiers in physiology · 2022Review
- Time-dependent alteration in the chemoreflex post-acute lung injury.Frontiers in physiology · 2022Article
- Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive.Scientific reports · 2021Article
- Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats.Frontiers in pharmacology · 2021Article
- Hypoxic Respiratory Chemoreflex Control in Young Trained Swimmers.Frontiers in physiology · 2021Article
- Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats.Scientific reports · 2020Article
- ERS International Congress, Madrid, 2019: highlights from the Sleep and Clinical Physiology Assembly.ERJ open research · 2020Review
- Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus.Aging · 2019Article
- Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?American journal of physiology. Heart and circulatory physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow per se can affect CB function. Then, we hypothesized that the CB-mediated chemoreflex drive will be enhanced only in low output HF but not in high output HF. Myocardial infarcted rats and aorto-caval fistulated rats were used as a low output HF model (MI-CHF) and as a high output HF model (AV-CHF), respectively. Blood flow supply to the CB region was decreased only in MI-CHF rats compared to Sham and AV-CHF rats. MI-CHF rats exhibited a significantly enhanced hypoxic ventilatory response compared to AV-CHF rats. However, apnea/hypopnea incidence was similarly increased in both MI-CHF and AV-CHF rats compared to control. Kruppel-like factor 2 expression, a flow sensitive transcription factor, was reduced in the CBs of MI-CHF rats but not in AV-CHF rats. Our results indicate that in the setting of HF, potentiation of the CB chemoreflex is strongly associated with a reduction in cardiac output and may not be related to other pathophysiological consequences of HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.