ArticleScientific reports2017
Cellular toxicity pathways of inorganic and methyl mercury in the green microalga Chlamydomonas reinhardtii.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 88 citations in OpenAlex.
- Microalgae Applications in the Agricultural and Food Sector: Towards a Sustainable Future.Molecules (Basel, Switzerland) · 2026Review
- Pet food safety at risk? Investigating toxic metal contamination in Lebanon and the UAE.RSC advances · 2025Article
- Diversity of Mercury-Tolerant Microorganisms.Microorganisms · 2025Review
- Transcriptomics Reveals an Energy-Saving Metabolic Switch in an Extremophilic Red MicroalgaInternational journal of molecular sciences · 2025Article
- Optimized Isolation of Lysosome-Related Organelles from Stationary Phase and Iron-OverloadedBio-protocol · 2024Article
- Mercury Accumulation Pathways in a Model Marine Microalgae: Sorption, Uptake, and Partition Kinetics.ACS ES&T water · 2024Article
- Reduction of Oxygen Production by Algal Cells in the Presence of O-Chlorobenzylidene Malononitrile.Bioengineering (Basel, Switzerland) · 2024Article
- Methylmercury Effect and Distribution in Two Extremophile Microalgae StrainsMicroorganisms · 2024Article
- Interaction of Naturally Occurring Phytoplankton with the Biogeochemical Cycling of Mercury in Aquatic Environments and Its Effects on Global Hg Pollution and Public Health.Microorganisms · 2023Review
- Metabolic alterations in algaEnvironmental science. Nano · 2022Article
- Is Genetic Engineering a Route to Enhance Microalgae-Mediated Bioremediation of Heavy Metal-Containing Effluents?Molecules (Basel, Switzerland) · 2022Review
- Metabolic turnover of cysteine-related thiol compounds at environmentally relevant concentrations byFrontiers in microbiology · 2022Article
- Microbe-assisted phytoremediation of environmental pollutants and energy recycling in sustainable agriculture.Archives of microbiology · 2021Review
- The Microbiology of Metal Mine Waste: Bioremediation Applications and Implications for Planetary Health.GeoHealth · 2021Review
- A 15,400-year record of natural and anthropogenic input of mercury (Hg) in a sub-alpine lacustrine sediment succession from the western Nanling Mountains, South China.Environmental science and pollution research international · 2020Article
- Article
- Instant Mercury Ion Detection in Industrial Waste Water with a Microchip Using Extended Gate Field-Effect Transistors and a Portable Device.Sensors (Basel, Switzerland) · 2019Article
- Improved Algal Toxicity Test System for RobustMetabolites · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contamination by mercury (Hg) is a worldwide concern because of Hg toxicity and biomagnification in aquatic food webs. Nevertheless, bioavailability and cellular toxicity pathways of inorganic (IHg) and methyl-Hg (MeHg) remain poorly understood. We analyzed the uptake, transcriptomic, and physiological responses in the microalga Chlamydomonas reinhardtii exposed to IHg or MeHg. Bioavailability of MeHg was up to 27× higher than for IHg. Genes involved in cell processes, energy metabolism and transport were dysregulated by both Hg species. Physiological analysis revealed an impact on photosynthesis and reduction-oxidation reaction metabolism. Nevertheless, MeHg dysregulated a larger number of genes and with a stronger fold-change than IHg at equivalent intracellular concentration. Analysis of the perturbations of the cell's functions helped to derive a detailed mechanistic understanding of differences in cellular handling of IHg and MeHg resulting in MeHg having a stronger impact. This knowledge is central for the prediction of impact of toxicants on organisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.