Evidence map›Paper›PMID 28808299›Full record

ArticleNature microbiology2017

Gut-homing Δ42PD1

Allen Ka Loon Cheung, Hau-Yee Kwok, Yiru Huang, Min Chen, Yufei Mo, Xilin Wu, Ka-Shing Lam, Hoi-Kuan Kong, Terrence Chi Kong Lau, Jingying Zhou and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. PD-1Journal for immunotherapy of cancer · 2025
    Article
  2. Article
  3. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018
    Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 2 countries.

Allen Ka Loon CheungAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Hau-Yee KwokAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Yiru HuangAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Min ChenAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Yufei MoAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Xilin WuAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Ka-Shing LamAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Hoi-Kuan KongDepartment of Biomedical Sciences, City University of Hong Kong, 999097, Hong Kong SAR, China.
Terrence Chi Kong LauDepartment of Biomedical Sciences, City University of Hong Kong, 999097, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-7505-7306
Jingying ZhouAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Jingjing LiAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Lin ChengAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Boon Kiat LeeAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Qiaoli PengHKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People's Hospital, 518000, Shenzhen, China.
Xiaofan LuSTD/HIV Research Laboratory and Department of Infectious Diseases, Beijing Key Laboratory of HIV/AIDS Research, Beijing You-An Hospital, Capital Medical University, 100000, Beijing, China.
Minghui AnKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, China Medical University, 110000, Shenyang, China.
Hui WangHKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People's Hospital, 518000, Shenzhen, China.
Hong ShangKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, China Medical University, 110000, Shenyang, China.
Boping ZhouHKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People's Hospital, 518000, Shenzhen, China.
Hao WuSTD/HIV Research Laboratory and Department of Infectious Diseases, Beijing Key Laboratory of HIV/AIDS Research, Beijing You-An Hospital, Capital Medical University, 100000, Beijing, China.
Aimin XuDepartment of Pharmacology & Pharmacy and Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Kwok-Yung YuenAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China.
Zhiwei ChenAIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, 999097, Hong Kong SAR, China. zchenai@hku.hk.ORCID http://orcid.org/0000-0002-4511-2888
University of Hong Kong · HKShenzhen Third People’s Hospital · CNCapital Medical University · CNCity University of Hong Kong · HKNational Health and Family Planning Commission · CNHKU-Pasteur Research Pole · HKYunnan Center for Disease Control And Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The innate immune cells underlying mucosal inflammatory responses and damage during acute HIV-1 infection remain incompletely understood. Here, we report a Vδ2 subset of gut-homing γδ T cells with significantly upregulated Δ42PD1 (a PD1 isoform) in acute (~20%) HIV-1 patients compared to chronic HIV-1 patients (~11%) and healthy controls (~2%). The frequency of Δ42PD1

Indexed as

Immunity, MucosalAnimalsBeijingCD4-Positive T-LymphocytesCell LineCell MovementCytokinesDisease Models, AnimalHIV-1HIV InfectionsHost-Pathogen InteractionsHumansImmunity, InnateIntestinesIntestine, SmallLipopolysaccharidesCC chemokine receptor 9CytokinesLipopolysaccharidesReceptors, CCRTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID28808299
OpenAlexW2746726011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.