ArticleJournal of breath research2017
Metabolomic profiles of plasma, exhaled breath condensate, and saliva are correlated with potential for air toxics detection.
Article in Journal of breath research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Metabolomics for exposure assessment and toxicity effects of occupational pollutants: current status and future perspectives.Metabolomics : Official journal of the Metabolomic Society · 2022Pooled it
- Respiratory Effects of Traffic-Related Air Pollution: A Randomized, Crossover Analysis of Lung Function, Airway Metabolome, and Biomarkers of Airway Injury.Environmental health perspectives · 2023Trial
- Particulate metal exposures induce plasma metabolome changes in a commuter panel study.PloS one · 2018Trial
- Recent Accomplishments in Exhaled Breath Condensate Analysis - Molecular Aspects.Current molecular medicine · 2026Review
- Metabolomics Signatures of Exposure to Ambient Air Pollution: A Large-Scale Metabolome-Wide Association Study in the Cancer Prevention Study-II Nutrition Cohort.Environmental science & technology · 2025Article
- Environmental tobacco smoke exposure is associated with increased levels of metals in children's saliva.Journal of exposure science & environmental epidemiology · 2023Article
- Salivary Metabolomic Signatures and Body Mass Index in Italian Adolescents: A Pilot Study.Journal of the Endocrine Society · 2023Article
- Saliva and Exhaled Breath Condensate Correlate With Serum in 4-12-Year-Olds Exposed to Secondhand Electronic Cigarette Vapors: A Pilot Study.Biological research for nursing · 2023Article
- Metabolic pathways altered by air pollutant exposure in association with lipid profiles in young adults.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.BMJ open respiratory research · 2023Article
- A State-of-the-Science Review on High-Resolution Metabolomics Application in Air Pollution Health Research: Current Progress, Analytical Challenges, and Recommendations for Future Direction.Environmental health perspectives · 2023Review
- Promising applications of human-derived saliva biomarker testing in clinical diagnostics.International journal of oral science · 2023Review
- The Oxidative Potential of Fine Particulate Matter and Biological Perturbations in Human Plasma and Saliva Metabolome.Environmental science & technology · 2022Article
- Evaluation of the Use of Saliva Metabolome as a Surrogate of Blood Metabolome in Assessing Internal Exposures to Traffic-Related Air Pollution.Environmental science & technology · 2022Article
- Assessment of metabolic perturbations associated with exposure to phthalates among pregnant African American women.The Science of the total environment · 2022Article
- Operationalizing the Exposome Using Passive Silicone Samplers.Current pollution reports · 2022Review
- Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution.Environmental research · 2021Article
- Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.Current environmental health reports · 2020Review
- Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.Environment international · 2019Observational
- Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies.Environment international · 2019Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionAdvances in the development of high-resolution metabolomics (HRM) have provided new opportunities for their use in characterizing exposures to environmental air pollutants and air pollution-related disease etiologies. Exposure assessment studies have considered blood, breath, and saliva as biological matrices suitable for measuring responses to air pollution exposures. The current study examines comparability among these three matrices using HRM and explores their potential for measuring mobile-source air toxics.
methodsFour participants provided saliva, exhaled breath concentrate (EBC), and plasma before and after a 2 h road traffic exposure. Samples were analyzed on a Thermo Scientific QExactive MS system in positive electrospray ionization mode and resolution of 70 000 full-width at half-maximum with C18 chromatography. Data were processed using an apLCMS and xMSanalyzer on the R statistical platform.
resultsThe analysis yielded 7110, 6019, and 7747 reproducible features in plasma, EBC, and saliva, respectively. Correlations were moderate-to-strong (R = 0.41-0.80) across all pairwise comparisons of feature intensity within profiles, with the strongest between EBC and saliva. The associations of mean intensities between matrix pairs were positive and significant, controlling for subject and sampling time effects. Six out of 20 features shared in all three matrices putatively matched a list of known mobile-source air toxics.
conclusionsPlasma, saliva, and EBC have largely comparable metabolic profiles measurable through HRM. These matrices have the potential to be used in identification and measurement of exposures to mobile-source air toxics, though further, targeted study is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.