Evidence map›Paper›PMID 28808057›Full record

ArticleThe Journal of biological chemistry2017

A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene

Mark B Meyer, Nancy A Benkusky, Martin Kaufmann, Seong Min Lee, Melda Onal, Glenville Jones, J Wesley Pike

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 87 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)The Journal of steroid biochemistry and molecular biology · 2025
    Article
  9. Article
  10. bioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.The Journal of steroid biochemistry and molecular biology · 2023
    Article
  15. Article
  16. Article
  17. Genomic mechanisms controlling renal vitamin D metabolism.The Journal of steroid biochemistry and molecular biology · 2023
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mark B MeyerFrom the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and markmeyer@wisc.edu.
Nancy A BenkuskyFrom the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and.
Martin Kaufmannthe Department of Biomedical and Molecular Sciences, Queen's University Kingston, Kingston, Ontario K7L 3N6, Canada.
Seong Min LeeFrom the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and.
Melda OnalFrom the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and.
Glenville JonesFrom the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and.
J Wesley PikeFrom the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 and.
University of Wisconsin–Madison · USQueen's University · CA

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

The vitamin D endocrine system regulates mineral homeostasis through its activities in the intestine, kidney, and bone. Terminal activation of vitamin D

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseAnimalsCalcitriolCholecalciferolFibroblast Growth Factor-23Gene DeletionGene Expression Regulation, EnzymologicHomeostasisKidneyMiceOrgan SpecificityVitamin D3 24-Hydroxylase25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolCholecalciferolCyp24a1 protein, mouseFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Vitamin D3 24-HydroxylaseChIP-sequencing (ChIP-seq)CRISPR/Cascyp24a1cyp27b1epigeneticsFGF23gene regulationPTHVDRvitamin D

Identifiers

PMID28808057
PMCPMC5655528
OpenAlexW2747982551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.