Evidence map›Paper›PMID 28808054›Full record

ArticleThe Journal of biological chemistry2017

MST4 kinase phosphorylates ACAP4 protein to orchestrate apical membrane remodeling during gastric acid secretion.

Xiao Yuan, Phil Y Yao, Jiying Jiang, Yin Zhang, Zeqi Su, Wendy Yao, Xueying Wang, Ping Gui, McKay Mullen, Calmour Henry and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Akt-elicited phosphorylation of Acapin steers cell migration.Journal of molecular cell biology · 2025
    Article
  3. Standard: Human gastric organoids.Cell regeneration (London, England) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Pathophysiological Roles of Actin-Binding Scaffold Protein, Ezrin.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Xiao YuanFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Phil Y Yaothe Beijing University of Chinese Medicine, Beijing 100029, China.
Jiying JiangFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Yin ZhangFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Zeqi SuFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Wendy Yaothe Keck Center for Cellular Dynamics, Morehouse School of Medicine, Atlanta, Georgia 30310.
Xueying WangFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Ping GuiFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
McKay Mullenthe Keck Center for Cellular Dynamics, Morehouse School of Medicine, Atlanta, Georgia 30310.
Calmour Henrythe Keck Center for Cellular Dynamics, Morehouse School of Medicine, Atlanta, Georgia 30310.
Tarsha WardFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Wenwen WangFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Larry Brakothe Keck Center for Cellular Dynamics, Morehouse School of Medicine, Atlanta, Georgia 30310.
Ruijun TianFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Xuannv Zhaothe Beijing University of Chinese Medicine, Beijing 100029, China.
Fengsong WangFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Xinwang Caothe Keck Center for Cellular Dynamics, Morehouse School of Medicine, Atlanta, Georgia 30310.
Dongmei WangFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China.
Xing LiuFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China, xing1017@ustc.edu.cn.
Xia Dingthe Beijing University of Chinese Medicine, Beijing 100029, China, dingx@bucm.edu.cn.
Xuebiao YaoFrom the BUCM-USTC Collaborative Center for Parietal Cell Research, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China, xyao@msm.edu.
University of Science and Technology of China · CNMorehouse School of Medicine · USCenter for Excellence in Molecular Cell Science · CNAnhui Medical University · CNBeijing University of Chinese Medicine · CN

Funding

The function of ezrin in stimulus-coupled acid secretionR01DK056292 · NIDDK · UNIVERSITY OF WISCONSIN MADISON · PI YAO, XUEBIAO · 1999 to 2012
$2.5M
Function of ACAP4 in CCL18-stimulated breast cancer metastasisR01CA164133 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI YAO, XUEBIAO · 2012 to 2016
$1.4M
FUNCTION OF MST4-EZRIN-ACAP4 SIGNALING IN GASTRIC PARIETAL CELL SECRETION AND HOMEOSTASISR01DK115812 · NIDDK · MOREHOUSE SCHOOL OF MEDICINE · PI YAO, XUEBIAO · 2017 to 2019
$967k
NCI NIH HHS R01 CA164133NIDDK NIH HHS R01 DK056292NIDDK NIH HHS R01 DK115812
6 · The paper itself

Abstract

Digestion in the stomach depends on acidification of the lumen. Histamine-elicited acid secretion is triggered by activation of the PKA cascade, which ultimately results in the insertion of gastric H,K-ATPases into the apical plasma membranes of parietal cells. Our recent study revealed the functional role of PKA-MST4-ezrin signaling axis in histamine-elicited acid secretion. However, it remains uncharacterized how the PKA-MST4-ezrin signaling axis operates the insertion of H,K-ATPases into the apical plasma membranes of gastric parietal cells. Here we show that MST4 phosphorylates ACAP4, an ARF6 GTPase-activating protein, at Thr

Indexed as

Models, BiologicalProtein Processing, Post-TranslationalAmino Acid SubstitutionAnimalsCell MembraneCell PolarityCells, CulturedComputational BiologyCytoskeletal ProteinsDatabases, ProteinEzrinGTPase-Activating ProteinsH(+)-K(+)-Exchanging ATPaseMicroscopy, Electron, TransmissionMutationParietal Cells, GastricCytoskeletal ProteinsEzrinGTPase-Activating ProteinsH(+)-K(+)-Exchanging ATPaseProtein Serine-Threonine KinasesRecombinant Fusion ProteinsADP ribosylation factor (ARF)exocytosisezrinMST2 (mammalian sterile 20-like kinase 2)protein phosphorylation

Identifiers

PMID28808054
PMCPMC5625048
OpenAlexW2747765271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.