Evidence map›Paper›PMID 28808019›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype.

Peter J Kerr, Isabella M Cattadori, June Liu, Derek G Sim, Jeff W Dodds, Jason W Brooks, Mary J Kennett, Edward C Holmes, Andrew F Read

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Peter J KerrMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Isabella M CattadoriCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802.
June LiuCSIRO Health and Biosecurity, Black Mountain Laboratories, Acton, ACT 2601, Australia.
Derek G SimCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802.
Jeff W DoddsDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.
Jason W BrooksDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.
Mary J KennettDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Andrew F ReadCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802; a.read@psu.edu.ORCID 0000-0001-7604-7903
Pennsylvania State University · USThe University of Sydney · AUCSIRO Health and Biosecurity · AU

Funding

Genomic analysis of the canonical case of virulence evolution: Myxomatosis in AuR01AI093804 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI READ, ANDREW F. · 2012 to 2016
$2.7M
NIAID NIH HHS R01 AI093804
6 · The paper itself

Abstract

In host-pathogen arms races, increases in host resistance prompt counteradaptation by pathogens, but the nature of that counteradaptation is seldom directly observed outside of laboratory models. The best-documented field example is the coevolution of myxoma virus (MYXV) in European rabbits. To understand how MYXV in Australia has continued to evolve in wild rabbits under intense selection for genetic resistance to myxomatosis, we compared the phenotypes of the progenitor MYXV and viral isolates from the 1950s and the 1990s in laboratory rabbits with no resistance. Strikingly, and unlike their 1950s counterparts, most virus isolates from the 1990s induced a highly lethal immune collapse syndrome similar to septic shock. Thus, the next step in this canonical case of coevolution after a species jump has been further escalation by the virus in the face of widespread host resistance.

Indexed as

AnimalsAustraliaBiological EvolutionMyxoma virusPoxviridae InfectionsRabbitsTime FactorsTumor Virus InfectionsVirulencecoevolutionemergent virusimmunosuppressionseptic shockvirulence

Identifiers

PMID28808019
PMCPMC5584459
OpenAlexW2746871493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.