Evidence map›Paper›PMID 28808010›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Voltage-gated calcium flux mediates

Giancarlo N Bruni, R Andrew Weekley, Benjamin J T Dodd, Joel M Kralj

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 152 citations in OpenAlex.

  1. Review
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  8. Article
  9. All Organisms Can Be Anesthetized, but There's No Point?BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  10. Osmotic stress triggers fast and reversible PMF collapse inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Long-Distance Electron Transport in Unicellular Organisms and Biofilms.Reviews of physiology, biochemistry and pharmacology · 2025
    Review
  18. Article
  19. Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Giancarlo N BruniDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303.ORCID 0000-0003-2850-4633
R Andrew WeekleyBioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303.
Benjamin J T DoddBioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303.
Joel M KraljDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303; joel.kralj@colorado.edu.ORCID 0000-0001-9370-2324
University of Colorado Boulder · US

Funding

Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
Neuronal electromics in health and diseaseDP2GM123458 · NIGMS · UNIVERSITY OF COLORADO · PI KRALJ, JOEL MARK · 2016 to 2016
$2.3M
Howard Hughes Medical InstituteNIGMS NIH HHS DP2 GM123458NIGMS NIH HHS T32 GM065103
6 · The paper itself

Abstract

Electrically excitable cells harness voltage-coupled calcium influx to transmit intracellular signals, typically studied in neurons and cardiomyocytes. Despite intense study in higher organisms, investigations of voltage and calcium signaling in bacteria have lagged due to their small size and a lack of sensitive tools. Only recently were bacteria shown to modulate their membrane potential on the timescale of seconds, and little is known about the downstream effects from this modulation. In this paper, we report on the effects of electrophysiology in individual bacteria. A genetically encoded calcium sensor expressed in

Indexed as

Mechanotransduction, CellularCalciumCalcium ChannelsEscherichia coliEscherichia coli ProteinsIon Channel GatingCalciumCalcium ChannelsEscherichia coli ProteinscalciumelectrophysiologyEscherichiamechanosensationvoltage

Identifiers

PMID28808010
PMCPMC5584419
OpenAlexW2748359871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.