Evidence map›Paper›PMID 28808009›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

A protein complex regulates RNA processing of intronic heterochromatin-containing genes in

Cheng-Guo Duan, Xingang Wang, Lingrui Zhang, Xiansong Xiong, Zhengjing Zhang, Kai Tang, Li Pan, Chuan-Chih Hsu, Huawei Xu, W Andy Tao and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 65 citations in OpenAlex.

  1. Biology · 2026
    Article
  2. A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis-regulatory Modules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  15. No Chance to Survive:Antibiotics (Basel, Switzerland) · 2023
    Article
  16. The MOM1 complex recruits the RdDM machinery via MORC6 to establishbioRxiv : the preprint server for biology · 2023
    Article
  17. Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Cheng-Guo DuanShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China; cgduan@sibs.ac.cn jkzhu@sibs.ac.cn.
Xingang WangDepartment of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907.
Lingrui ZhangShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China.
Xiansong XiongShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China.
Zhengjing ZhangShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China.
Kai TangDepartment of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907.
Li PanDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Chuan-Chih HsuDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Huawei XuShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China.
W Andy TaoDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907.
Heng ZhangShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China.
Jian-Kang ZhuShanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai 200032, China; cgduan@sibs.ac.cn jkzhu@sibs.ac.cn.ORCID 0000-0001-5134-731X
Chinese Academy of Sciences · CNPurdue University West Lafayette · USHenan University of Science and Technology · CN

Funding

DNA Demethylation and Transcriptional Gene SilencingR01GM070795 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHU, JIAN-KANG · 2004 to 2015
$4.0M
NIGMS NIH HHS R01 GM070795
6 · The paper itself

Abstract

In several eukaryotic organisms, heterochromatin (HC) in the introns of genes can regulate RNA processing, including polyadenylation, but the mechanism underlying this regulation is poorly understood. By promoting distal polyadenylation, the bromo-adjacent homology (BAH) domain-containing and RNA recognition motif-containing protein ASI1 and the H3K9me2-binding protein EDM2 are required for the expression of functional full-length transcripts of intronic HC-containing genes in

Indexed as

ArabidopsisArabidopsis ProteinsDNA-Binding ProteinsDNA MethylationEpigenesis, GeneticGene ExpressionGene Expression Regulation, PlantHeterochromatinHistonesIntronsJumonji Domain-Containing Histone DemethylasesMultiprotein ComplexesMutationPolyadenylationRNARNA-Binding ProteinsArabidopsis ProteinsASI1 protein, ArabidopsisDNA-Binding ProteinsEDM2 protein, ArabidopsisHeterochromatinHistonesIBM1 protein, ArabidopsisJumonji Domain-Containing Histone DemethylasesMultiprotein ComplexesRNARNA-Binding ProteinsTranscription FactorsDNA methylationheterochromatinpolyadenylationRNA processingtransposable element

Identifiers

PMID28808009
PMCPMC5584460
OpenAlexW2746657656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.